dixyrazine
Sign in to saveDixyrazine, also known as dixypazin (oxalate), sold under the brand names Ansiolene, Esocalm, Esucos, Metronal, and Roscal, is a typical antipsychotic of the phenothiazine group described as a neuroleptic and antihistamine. It was first introduced in Germany in 1969. It is used as a neuroleptic, anxiolytic, and antihistamine in doses between 12.5 and 75 mg a day. ==Synthesis== class=skin-invert-image|thumb|center|500px|Synthesis of dixyrazine
Chemical data
- Formula
- C24H33N3O2S
- Molecular weight
- 427.6 g/mol
- IUPAC name
- 2-[2-[4-(2-methyl-3-phenothiazin-10-ylpropyl)piperazin-1-yl]ethoxy]ethanol
via PubChem
Research
106 papers- Dixyrazine for the prevention of postoperative nausea and vomiting after laparoscopic cholecystectomy.Acta anaesthesiologica Scandinavica · 2004
- Betamethasone-dixyrazine versus metoclopramide as antiemetic treatment in cancer chemotherapy.Acta oncologica (Stockholm, Sweden) · 1988
- Dixyrazine premedication for cataract surgery. A comparison with diazepam.Acta anaesthesiologica Scandinavica · 1994
- Dixyrazine, a phenothiazine derivative, can prevent brain oedema induced by intracarotid injection of protamine sulphate.Acta neurochirurgica · 1991
- [DIXYRAZINE IN PSYCHIATRY].Gazzetta medica italiana · 1964
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Wikidata facts
- Subclass of
- chemical compound
- Mass
- +427.229
Show 1 more fact
- P2868
- antiemetic
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Article
2 sectionsContents
- Synthesis
- References
Dixyrazine, also known as dixypazin (oxalate), sold under the brand names Ansiolene, Esocalm, Esucos, Metronal, and Roscal, is a typical antipsychotic of the phenothiazine group described as a neuroleptic and antihistamine. It was first introduced in Germany in 1969. It is used as a neuroleptic, anxiolytic, and antihistamine in doses between 12.5 and 75 mg a day. ==Synthesis== class=skin-invert-image|thumb|center|500px|Synthesis of dixyrazine
Sodamide alkylation of phenothiazine (1) with 1-bromo-3-chloro-2-methylpropane (2) gives 10-(3-Chloro-2-methylpropyl)phenothiazine (3). Completion of the sidechain by alkylation with 1-[2-(2-hydroxyethoxy)ethyl]piperazine (4) and displacement of the halogen completes the synthesis of dixyrazine (5).