Structure via PubChem · Public domain (PubChem)
dorzolamide/timolol
Sign in to saveAlso known as dorzolamide / Timolol
Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. It is a combination of dorzolamide hydrochloride and timolol maleate. It may be used when a beta blocker, like timolol, is not sufficient alone. It is used as an eye drop.
Chemical data
- Formula
- C23H40N6O7S4
- Molecular weight
- 640.9 g/mol
- IUPAC name
- (2S)-1-(tert-butylamino)-3-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]propan-2-ol;(4R,6R)-4-(ethylamino)-6-methyl-7,7-dioxo-5,6-dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide
- SMILES
- CCN[C@@H]1C[C@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O
- InChIKey
- KSBKLOORIKSXDP-BWJWWNBBSA-N
- Polar surface area
- 259 Ų
- H-bond donors
- 4
- H-bond acceptors
- 15
- Formal charge
- 0
via PubChem
Wikidata facts
- Instance of
- mixture
- Has part
- (S)-(−)-timolol
- Mass
- 640.8649
- Has use
- medication
Show 4 more facts
- canonical SMILES
- CCNC1CC(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.CC(C)(C)NCC(COC1=NSN=C1N2CCOCC2)O
- isomeric SMILES
- CCN[C@@H]1C[C@H](S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)C.CC(C)(C)NC[C@@H](COC1=NSN=C1N2CCOCC2)O
- medical condition treated
- ocular hypertension
- chemical formula
- C₂₃H₄₀N₆O₇S₄
Sources (1)
via Wikidata · CC0
~5 min read
Encyclopedic overview
5 sectionsContents
- Adverse effects
- Pharmacology
- Comparison to other products
- History
- References
Dorzolamide/timolol, sold under the brand name Cosopt among others, is a medication used to treat high pressure inside the eye including glaucoma. It is a combination of dorzolamide hydrochloride and timolol maleate. It may be used when a beta blocker, like timolol, is not sufficient alone. It is used as an eye drop.
Common side effects include eye discomfort, eye redness, taste changes, and blurry vision. Serious side effects may include allergic reactions and heart failure. Use is not recommended in those with asthma, a sulfonamide allergy, or a slow heart rate. Dorzolamide is a carbonic anhydrase inhibitor and timolol is a beta blocker. Both work by decreasing the amount of aqueous humor made by the eye.
Excerpted from Wikipedia’s “dorzolamide/timolol” article, available under the CC BY-SA 4.0 licence.
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