brinzolamide

Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Chemical data

Formula: C12H21N3O5S3
Molecular weight: 383.5 g/mol
IUPAC name: (4R)-4-(ethylamino)-2-(3-methoxypropyl)-1,1-dioxo-3,4-dihydrothieno[3,2-e]thiazine-6-sulfonamide
SMILES: CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
InChIKey: HCRKCZRJWPKOAR-JTQLQIEISA-N
XLogP: -0.3
Polar surface area: 164 Å²
H-bond donors: 2
H-bond acceptors: 9
Formal charge: 0

via PubChem

Research

508 papers

Brinzolamide.2006
Brinzolamide.Expert opinion on pharmacotherapy · 2008
Preclinical overview of brinzolamide.Survey of ophthalmology · 2000
Brinzolamide/brimonidine: a review of its use in patients with open-angle glaucoma or ocular hypertension.Drugs & aging · 2015
Brinzolamide-induced Follicular Conjunctivitis.Journal of glaucoma · 2018

via PubMed

Wikidata facts

Mass: 383.064

Show 6 more facts

defined daily dose: 0.2
chemical formula: C₁₂H₂₁N₃O₅S₃
World Health Organisation international non-proprietary name: brinzolamide
isomeric SMILES: CCN[C@H]1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC
Commons category: Brinzolamide
canonical SMILES: CCNC1CN(S(=O)(=O)C2=C1C=C(S2)S(=O)(=O)N)CCCOC

Sources (5)

via Wikidata · CC0

~4 min read

Article

16 sections

Contents

Chemistry
Indications
Pharmacodynamics
Pharmacokinetics
Absorption
Distribution
Metabolism
Excretion
Cautions
Side effects
Precautions
Combinations
With timolol
With brimonidine
References
Further reading

Brinzolamide (trade name Azopt) is a carbonic anhydrase inhibitor used to lower intraocular pressure in patients with open-angle glaucoma or ocular hypertension.

Brinzolamide was approved as a generic medication in the United States in November 2020.