Structure via PubChem · Public domain (PubChem)
befunolol
Sign in to saveAlso known as (RS)-1-{7-[2-hydroxy-3-(propan-2-ylamino)propoxy]- 1-benzofuran-2-yl}ethanone
Befunolol (INN) is a beta blocker with intrinsic sympathomimetic activity used in the management of open-angle glaucoma. It also acts as a β adrenoreceptor partial agonist. Befunolol was introduced in Japan in 1983 by Kakenyaku Kako Co. under the trade name Bentos.
Chemical data
- Formula
- C16H21NO4
- Molecular weight
- 291.34 g/mol
- IUPAC name
- 1-[7-[2-hydroxy-3-(propan-2-ylamino)propoxy]-1-benzofuran-2-yl]ethanone
- SMILES
- CC(C)NCC(COC1=CC=CC2=C1OC(=C2)C(=O)C)O
- InChIKey
- ZPQPDBIHYCBNIG-UHFFFAOYSA-N
- XLogP
- 2
- Polar surface area
- 71.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- glaucoma
via ChEMBL · EBI
Research
126 papers- Purification and characterization of befunolol reductase from rabbit liver.Chemical & pharmaceutical bulletin · 1989
- Long-term effects of befunolol on the corneal endothelium and the consensual ophthalmotonic reaction.Clinical therapeutics · 1992
- A beta-adrenergic partial agonist (befunolol) discriminates two different affinity sites.Japanese journal of pharmacology · 1986
- A derivative of befunolol, BFE-55, interacts with only the high affinity sites in beta-adrenoceptors.Canadian journal of physiology and pharmacology · 1987
- A beta-adrenoceptor blocking agent, befunolol as a partial agonist in isolated organs.General pharmacology · 1985
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 291.147
Show 3 more facts
- subject has role
- beta blocker
- chemical formula
- C₁₆H₂₁NO₄
- canonical SMILES
- CC(C)NCC(COC1=CC=CC2=C1OC(=C2)C(=O)C)O
Sources (2)
via Wikidata · CC0
~2 min read
Encyclopedic overview
2 sectionsContents
- Synthesis
- References
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| tradename = Benfuran, Bentos, Betaclar, Glauconex | Drugs.com = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration =
Excerpted from Wikipedia’s “befunolol” article, available under the CC BY-SA 4.0 licence.