Structure via PubChem · Public domain (PubChem)
دروكسيدوبا
Sign in to saveAlso known as L-DOPS, Northera®, SM-5688, (-)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid, (2S,3R)-3,4-dihydroxy-phenylserine, L-Threodops, SM 5688, threo-Dopaserine
مركب كيميائي
Chemical data
- Formula
- C9H11NO5
- Molecular weight
- 213.19 g/mol
- IUPAC name
- (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
- SMILES
- C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O
- InChIKey
- QXWYKJLNLSIPIN-JGVFFNPUSA-N
- XLogP
- -3.2
- Polar surface area
- 124 Ų
- H-bond donors
- 5
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2014
- Admin. routes
- oral
- Indications
- hypotension, orthostatic hypotension, fibromyalgia, cardiovascular disease
via ChEMBL · EBI
Research
483 papers- Droxidopa.2012
- Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review.Cureus · 2023
- Droxidopa for Vasopressor Weaning in Critically Ill Patients with Persistent Hypotension: A Multicenter, Retrospective, Single-Arm Observational Study.Journal of intensive care medicine · 2025
- Droxidopa in Critical Care: A Systematic Review of an Emerging Off-Label Practice.Critical care research and practice · 2025
- Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases.Expert opinion on pharmacotherapy · 2019
via PubMed
Wikidata facts
- Subclass of
- catecholamine
- Mass
- 213.063722
- Has use
- medication
Show 9 more facts
- chemical formula
- C₉H₁₁NO₅
- Commons category
- Droxidopa
- canonical SMILES
- C1=CC(=C(C=C1C(C(C(=O)O)N)O)O)O
- World Health Organisation international non-proprietary name
- droxidopa
- isomeric SMILES
- N[C@@H]([C@H](O)C1=CC=C(O)C(O)=C1)C(O)=O
- NCI Thesaurus ID
- C73266
- subject has role
- antiparkinson
- medical condition treated
- Parkinson's disease
- legal status (medicine)
- boxed warning
via Wikidata · CC0
Article · العربية
دروكسيدوبا (بالإنجليزية: Droxidopa)؛ هو سالف حمض أميني مُصطنَع حيويًّا، يعمل دواءً أوليًّا للناقل العصبي نورإبينفرين (نورأدرينالين). وعلى عكس النورإبينفرين، فإن دروكسيدوبا قادرٌ على عبور الحاجز الدموي الدماغي (BBB) الواقي.
Abstract from DBpedia / Wikipedia · CC BY-SA