Structure via PubChem · Public domain (PubChem)
ドロキシドパ
Sign in to saveAlso known as L-DOPS, Northera®, SM-5688, (-)-(2S,3R)-2-amino-3-hydroxy-3-(3,4-dihydroxyphenyl)propanoic acid, (2S,3R)-3,4-dihydroxy-phenylserine, L-Threodops, SM 5688, threo-Dopaserine
Droxidopa, also known as 'L-threo-dihydroxyphenylserine (L-DOPS) and sold under the brand names Northera and Dops' among others, is sympathomimetic medication which is used in the treatment of hypotension (low blood pressure) and for other indications. It is taken by mouth.
Chemical data
- Formula
- C9H11NO5
- Molecular weight
- 213.19 g/mol
- IUPAC name
- (2S,3R)-2-amino-3-(3,4-dihydroxyphenyl)-3-hydroxypropanoic acid
- SMILES
- C1=CC(=C(C=C1[C@H]([C@@H](C(=O)O)N)O)O)O
- InChIKey
- QXWYKJLNLSIPIN-JGVFFNPUSA-N
- XLogP
- -3.2
- Polar surface area
- 124 Ų
- H-bond donors
- 5
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2014
- Admin. routes
- oral
- Indications
- hypotension, orthostatic hypotension, fibromyalgia, cardiovascular disease
via ChEMBL · EBI
Research
483 papers- Droxidopa.2012
- Ampreloxetine Versus Droxidopa in Neurogenic Orthostatic Hypotension: A Comparative Review.Cureus · 2023
- Droxidopa for Vasopressor Weaning in Critically Ill Patients with Persistent Hypotension: A Multicenter, Retrospective, Single-Arm Observational Study.Journal of intensive care medicine · 2025
- Droxidopa in Critical Care: A Systematic Review of an Emerging Off-Label Practice.Critical care research and practice · 2025
- Droxidopa for the treatment of neurogenic orthostatic hypotension in neurodegenerative diseases.Expert opinion on pharmacotherapy · 2019
via PubMed
Wikidata facts
- Subclass of
- catecholamine
- Mass
- 213.063722
- Has use
- medication
Show 9 more facts
- chemical formula
- C₉H₁₁NO₅
- Commons category
- Droxidopa
- canonical SMILES
- C1=CC(=C(C=C1C(C(C(=O)O)N)O)O)O
- World Health Organisation international non-proprietary name
- droxidopa
- isomeric SMILES
- N[C@@H]([C@H](O)C1=CC=C(O)C(O)=C1)C(O)=O
- NCI Thesaurus ID
- C73266
- subject has role
- antiparkinson
- medical condition treated
- Parkinson's disease
- legal status (medicine)
- boxed warning
via Wikidata · CC0
Article · 日本語
ドロキシドパ（一般名：Droxidopa、L-threo-dihydroxyphenylserine、 商品名：ドプス、Northera）は、アドレナリン受容体刺激薬であるノルアドレナリンおよびアドレナリンのプロドラッグとして作用する、合成アミノ酸前駆体である。ノルアドレナリンや アドレナリンとは異なり血液脳関門を通過可能である。
Abstract from DBpedia / Wikipedia · CC BY-SA