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دوتاستراید

Structure via PubChem · Public domain (PubChem)

EntityQ424760· pop 23· linked from 353 articles

دوتاستراید

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Also known as alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide, (5alpha,17beta)-N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide

Dutasteride, sold under the brand name Avodart among others, is a medication primarily used to treat the symptoms of a benign prostatic hyperplasia (BPH), an enlarged prostate not associated with cancer. A few months may be required before benefits occur. It is also used for scalp hair loss in men and as a part of hormone therapy in transgender women. It is usually taken by mouth.

Key facts

Drug.ChEMBL
1200969
Drug.Verifiedfields
verified
Drug.Watchedfields
verified
Drug.verifiedrevid
461091686
Drug.image
Dutasteride.svg
Drug.image_class
skin-invert-image
Drug.width
250
Drug.tradename
Avodart, others
Drug.MedlinePlus
a603001
Drug.DailyMedID
Dutasteride
Drug.pregnancy_category
Not to be used during pregnancy
Drug.routes_of_administration
By mouth
Drug.class
5α-Reductase inhibitor
Drug.ATC_prefix
G04
Drug.ATC_suffix
CB02
Drug.legal_UK
POM
Drug.legal_US
Rx-only
Drug.bioavailability
60%

via Wikipedia infobox

Chemical data

Formula
C27H30F6N2O2
Molecular weight
528.5 g/mol
IUPAC name
(1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
SMILES
C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
InChIKey
JWJOTENAMICLJG-QWBYCMEYSA-N
XLogP
5.4
Polar surface area
58.2 Ų
H-bond donors
2
H-bond acceptors
8
Formal charge
0

via PubChem

Gallery (3)