dutasteride

Also known as alpha,alpha,alpha,alpha',alpha',alpha'-hexafluoro-3-oxo-4-aza-5alpha-androst-1-ene-17beta-carboxy-2',5'-xylidide, (5alpha,17beta)-N-[2,5-bis(trifluoromethyl)phenyl]-3-oxo-4-azaandrost-1-ene-17-carboxamide

médicament

In the Vinony graph

Vinony's link graph records 353 inbound references to dutasteride, and connects out to biological half-life, International Standard Serial Number and patent.

It is catalogued under topics including 5α-Reductase inhibitors, Androstanes and Carboxamides.

Vinony links it to 22 Wikipedia language editions.

Key facts

Drug.ChEMBL: 1200969
Drug.Verifiedfields: verified
Drug.Watchedfields: verified
Drug.verifiedrevid: 461091686
Drug.image: Dutasteride.svg
Drug.image_class: skin-invert-image
Drug.width: 250
Drug.tradename: Avodart, others
Drug.MedlinePlus: a603001
Drug.DailyMedID: Dutasteride
Drug.pregnancy_category: Not to be used during pregnancy
Drug.routes_of_administration: By mouth
Drug.class: 5α-Reductase inhibitor
Drug.ATC_prefix: G04
Drug.ATC_suffix: CB02
Drug.legal_UK: POM
Drug.legal_US: Rx-only
Drug.bioavailability: 60%

via Wikipedia infobox

Chemical data

Formula: C27H30F6N2O2
Molecular weight: 528.5 g/mol
IUPAC name: (1S,3aS,3bS,5aR,9aR,9bS,11aS)-N-[2,5-bis(trifluoromethyl)phenyl]-9a,11a-dimethyl-7-oxo-1,2,3,3a,3b,4,5,5a,6,9b,10,11-dodecahydroindeno[5,4-f]quinoline-1-carboxamide
SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
InChIKey: JWJOTENAMICLJG-QWBYCMEYSA-N
XLogP: 5.4
Polar surface area: 58.2 Å²
H-bond donors: 2
H-bond acceptors: 8
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2001
Admin. routes: oral
Indications: prostate carcinoma, benign prostatic hyperplasia, prostate adenocarcinoma, androgenetic alopecia

via ChEMBL · EBI

Wikidata facts

Mass: 528.221
Has use: medication

Show 7 more facts

chemical formula: C₂₇H₃₀F₆N₂O₂
World Health Organisation international non-proprietary name: dutasteride
canonical SMILES: CC12CCC3C(C1CCC2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CCC5C3(C=CC(=O)N5)C
isomeric SMILES: C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2C(=O)NC4=C(C=CC(=C4)C(F)(F)F)C(F)(F)F)CC[C@@H]5[C@@]3(C=CC(=O)N5)C
defined daily dose: 0.5
subject has role: 5-alpha-reductase inhibitors
Commons category: Dutasteride