DYNC1H1
Sign in to saveAlso known as DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3
Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene. Dynein is a molecular motor protein that is responsible for the transport of numerous cellular cargoes to minus ends of microtubules, which are typically found in the center of a cell, or the cell body of neurons. It is located on the 14th chromosome at position 14q32.31. Cytoplasmic dynein transports cargoes along the axon in the retrograde direction, bringing materials from the axon to the cell body. Dynein heavy chain binds microtubules and hydrolyzes ATP at its C-terminal head. It binds cargo via
Gene data
DYNC1H1- Name
- dynein cytoplasmic 1 heavy chain 1
- Type
- protein-coding
- Position
- 101,964,573–102,056,443 (+)
- Aliases
- CDCBM13, CMT2O, DHC1, DHC1a, DNCH1, DNCL, DNECL, DYHC, Dnchc1, HL-3
- Ensembl
- ENSG00000197102
- RefSeq RNA
- NM_001376.5
- RefSeq protein
- NP_001367.2
Dyneins are a group of microtubule-activated ATPases that function as molecular motors. They are divided into two subgroups of axonemal and cytoplasmic dyneins. The cytoplasmic dyneins function in intracellular motility, including retrograde axonal transport, protein sorting, organelle movement, and spindle dynamics. Molecules of conventional cytoplasmic dynein are comprised of 2 heavy chain polypeptides and a number of intermediate and light chains.This gene encodes a member of the cytoplasmic dynein heavy chain family. [provided by RefSeq, Oct 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Wikidata facts
- Image
- Protein DYNC1H1 PDB 2BOR.png
Show 5 more facts
- HomoloGene ID
- 1053
- exact match
- identifiers.org/ncbigene/1778
- genomic end
- 102056443
- genomic start
- 101964573
- cytogenetic location
- 14q32.31
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Article
6 sectionsContents
- Interactions
- Clinical relevance
- Society and Culture
- References
- Further reading
- External links
Cytoplasmic dynein 1 heavy chain 1 is a protein that in humans is encoded by the DYNC1H1 gene. Dynein is a molecular motor protein that is responsible for the transport of numerous cellular cargoes to minus ends of microtubules, which are typically found in the center of a cell, or the cell body of neurons. It is located on the 14th chromosome at position 14q32.31. Cytoplasmic dynein transports cargoes along the axon in the retrograde direction, bringing materials from the axon to the cell body. Dynein heavy chain binds microtubules and hydrolyzes ATP at its C-terminal head. It binds cargo via interaction with other dynein subunits at its N-terminal tail.
==Interactions== DYNC1H1 has been shown to interact with a large variety of proteins that act as adaptors and regulators. The dynein motor protein complex itself is a large, 1.4 MDa multimeric complex composed of dimerized heavy chains, two intermediate chains, two light intermediate chains, and additional light chains. Other well known adaptors and regulators are Dynactin, PAFAH1B1 and CDC5L.