DYNLRB1
Sign in to saveAlso known as BITH, BLP, DNCL2A, DNLC2A, ROBLD1, dynein light chain roadblock-type 1
Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.
Gene data
DYNLRB1- Name
- dynein light chain roadblock-type 1
- Type
- protein-coding
- Position
- 34,515,600–34,540,958 (+)
- Aliases
- BITH, BLP, DNCL2A, DNLC2A, ROBLD1
- Ensembl
- ENSG00000125971
- RefSeq RNA
- NM_001319157.2, NM_001382365.1, NM_001382366.1, NM_001382367.1, NM_014183.4
- RefSeq protein
- NP_001306086.1, NP_001369294.1, NP_001369295.1, NP_001369296.1, NP_054902.1
This gene is a member of the roadblock dynein light chain family. The encoded cytoplasmic protein is capable of binding intermediate chain proteins, interacts with transforming growth factor-beta, and has been implicated in the regulation of actin modulating proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 12 and 18. [provided by RefSeq, Aug 2013].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
dynein light chain roadblock-type 1
- Symbol
- DYNLRB1
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 20:34,515,600-34,540,958
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- Protein DYNLRB1 PDB 1y4o.png
Show 7 more facts
- HomoloGene ID
- 69161
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/83658
- genomic end
- 33128762
- genomic start
- 33104214
- chromosome
- human chromosome 20
- cytogenetic location
- 20q11.22
Sources (3)
via Wikidata · CC0
~1 min read
Encyclopedic overview
3 sectionsContents
- References
- Further reading
- External links
Dynein light chain roadblock-type 1 is a protein that in humans is encoded by the DYNLRB1 gene.
This gene is a member of the roadblock dynein light chain family and encodes a cytoplasmic protein that is capable of binding intermediate chain proteins. Upregulation of this gene has been associated with hepatocellular carcinomas, suggesting that this gene may be involved in tumor progression.
Excerpted from Wikipedia’s “DYNLRB1” article, available under the CC BY-SA 4.0 licence.