E-6801

Also known as E 6801

E-6801 is a partial agonist of the 5-HT6 receptor. It enhanced recognition memory and reversed the memory deficits of scopolamine in an object recognition task in a rat model. The mechanism of memory enhancement is due to a combined modulation of cholinergic and glutamatergic neurotransmission.

In the Vinony graph

Within Vinony's link graph, E-6801 is referenced by 1,585 other articles, and connects out to tryptamines, N-methylserotonin and 5-methoxytryptamine.

It sits within the topics 5-HT6 agonists, Anorectics and Chloroarenes.

Its subject is documented across 5 Wikipedia language editions.

Chemical data

Formula: C17H18ClN5O2S2
Molecular weight: 423.9 g/mol
IUPAC name: 6-chloro-N-[3-[2-(dimethylamino)ethyl]-1H-indol-5-yl]imidazo[2,1-b][1,3]thiazole-5-sulfonamide
SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)NS(=O)(=O)C3=C(N=C4N3C=CS4)Cl
InChIKey: RZAXUKVIIWUIOM-UHFFFAOYSA-N
XLogP: 4.1
Polar surface area: 119 Å²
H-bond donors: 2
H-bond acceptors: 6
Formal charge: 0

via PubChem

Drug data · ChEMBL

Molecule type: Small molecule

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 423.059045

Show 2 more facts

chemical formula: C₁₇H₁₈ClN₅O₂S₂
canonical SMILES: CN(C)CCC1=CNC2=C1C=C(C=C2)NS(=O)(=O)C3=C(N=C4N3C=CS4)Cl

Sources (2)

via Wikidata · CC0

~1 min read

Encyclopedic overview

2 sections

Contents

See also
References

{{Chembox | ImageFile = E_6801.svg | ImageClass = skin-invert-image | ImageSize = | ImageAlt = | PIN = 6-Chloro-N-{3-[2-(dimethylamino)ethyl]-1H-indol-5-yl}imidazo[2,1-b][1,3]thiazole-5-sulfonamide | OtherNames = |Section1= |Section2= |Section3= }}

Excerpted from Wikipedia’s “E-6801” article, available under the CC BY-SA 4.0 licence.