Ectodomain
Sign in to saveAn ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction. A notable example of an ectodomain is the S protein, commonly known as the spike protein, of the viral particle responsible for the COVID-19 pandemic. The ectodomain region of the spike protein (S) is essential for attachment and eventual entry of the viral protein into the host cell.
In the Vinony graph
Vinony's link graph records 78 inbound references to Ectodomain, and connects out to COVID-19 pandemic, cell and protein.
Vinony files it under Protein domains and Protein structure.
Vinony links it to 5 Wikipedia language editions.
~2 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction. A notable example of an ectodomain is the S protein, commonly known as the spike protein, of the viral particle responsible for the COVID-19 pandemic. The ectodomain region of the spike protein (S) is essential for attachment and eventual entry of the viral protein into the host cell.
Ectodomains play a crucial part in the signaling pathways of viruses. Recent findings have indicated that certain antibodies including the anti-receptor binding domain (anti-RBD) or anti-spike ectodomain (anti-ECD) IgG titers can act as virus neutralization titers (VN titers) which can be identified in individuals with diseases, dyspnea and hospitalizations. In perspective of severe acute respiratory syndrome corona virus 2 (SARS-Cov-2) these specific ectodomains may detect antibody efficacy against SARS-Cov-2, in which VN titers can classify eligible plasma donors. Protective measures against diseases and respiratory conditions can further be advanced through ongoing research on ectodomains. Ectodomain's play a crucial part in the signaling pathways of viruses. In perspective of severe acute respiratory syndrome corona virus 2 (SARS-Cov-2) these specific ectodomains may detect antibody efficacy against SARS-Cov-2, in which VN titers can classify eligible plasma donors. Protective measures against diseases and respiratory conditions can further be advanced through ongoing research on ectodomains.
Excerpted from Wikipedia’s “Ectodomain” article, available under the CC BY-SA 4.0 licence.