Also known as CD155, HVED, NECL5, Necl-5, PVS, TAGE4, poliovirus receptor, PVR cell adhesion molecule
CD155 (cluster of differentiation 155), also known as the poliovirus receptor, is a protein that in humans is encoded by the PVR gene. It is a transmembrane protein that is involved in forming junctions between neighboring cells. It is also the molecule that poliovirus uses to enter cells. The gene is specific to the primates.
Gene data
PVR- Name
- PVR cell adhesion molecule
- Type
- protein-coding
- Position
- 44,643,798–44,666,162 (+)
- Aliases
- CD155, HVED, NECL5, Necl-5, PVS, TAGE4
- Ensembl
- ENSG00000073008
- RefSeq RNA
- NM_001135768.3, NM_001135769.3, NM_001135770.4, NM_006505.5
- RefSeq protein
- NP_001129240.1, NP_001129241.1, NP_001129242.2, NP_006496.4
The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008].
Gene Ontology
Biological process
Molecular function
Pathways
via MyGene.info
Gene · Ensembl
PVR cell adhesion molecule
- Symbol
- PVR
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 19:44,643,798-44,666,162
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
~2 min read
Encyclopedic overview
6 sectionsContents
- Function
- Polio
- Structure
- References
- External links
- Further reading
CD155 (cluster of differentiation 155), also known as the poliovirus receptor, is a protein that in humans is encoded by the PVR gene. It is a transmembrane protein that is involved in forming junctions between neighboring cells. It is also the molecule that poliovirus uses to enter cells. The gene is specific to the primates.
== Function ==
Excerpted from Wikipedia’s “PVR” article, available under the CC BY-SA 4.0 licence.