English

English Deutsch Español Français Italiano Nederlands Português Svenska العربية

GeneQ18032703· pop 5· linked from 10 articles

LHX3

Sign in to save

Also known as CPHD3, LIM3, M2-LHX3, LIM homeobox 3

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

Gene data

LHX3

Name: LIM homeobox 3
Type: protein-coding
Position: 136,196,250–136,205,128 (−)
Aliases: CPHD3, LIM3, M2-LHX3
Ensembl: ENSG00000107187
RefSeq RNA: NM_001363746.1, NM_014564.5, NM_178138.6, XM_017015168.1, XM_054363881.1
RefSeq protein: NP_001350675.1, NP_055379.1, NP_835258.1, XP_016870657.1, XP_054219856.1

This gene encodes a member of a large family of proteins which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Mutations in this gene cause combined pituitary hormone deficiency 3. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II animal organ morphogenesis neuron differentiation positive regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase II inner ear development

Molecular function

transcription cis-regulatory region binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator binding transcription coactivator binding DNA-binding transcription activator activity, RNA polymerase II-specific

Cellular component

chromatin chromatin nucleus nucleus nucleus transcription regulator complex

Pathways

Developmental Biology Signaling by ROBO receptors Axon guidance Regulation of expression of SLITs and ROBOs Nervous system development

via MyGene.info

Gene · Ensembl

LIM homeobox 3

Symbol: LHX3
Biotype: Protein coding
Organism: Homo sapiens
Location: 9:136,196,250-136,205,128
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 7 more facts

HomoloGene ID: 7814
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/8022
genomic end: 136205128
genomic start: 139088096
chromosome: human chromosome 9
cytogenetic location: 9q34.3

Sources (3)

via Wikidata · CC0

~1 min read

Encyclopedic overview

6 sections

Contents

Function
Clinical significance
Interactions
References
Further reading
External links

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the LHX3 gene.

== Function ==

Excerpted from Wikipedia’s “LHX3” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0