Encainide

Also known as (+-)-4-Methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide, 4-Methoxy-2'-[2-(1-methyl-2-piperidyl)ethyl]benzanilide, 4-Methoxy-N-{2-[2-(1-methyl-piperidin-2-yl)-ethyl]-phenyl}-benzamide, (+-)-2'-[2-(1-Methyl-2-piperidyl)ethyl]-P-anisanilide, Encainida, Encainidum, (±)-4-methoxy-N-(2-(2-(1-methyl-2-piperidinyl)ethyl)phenyl)benzamide

farmaco

Chemical data

Formula: C22H28N2O2
Molecular weight: 352.5 g/mol
IUPAC name: 4-methoxy-N-[2-[2-(1-methylpiperidin-2-yl)ethyl]phenyl]benzamide
SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
InChIKey: PJWPNDMDCLXCOM-UHFFFAOYSA-N
XLogP: 4.3
Polar surface area: 41.6 Å²
H-bond donors: 1
H-bond acceptors: 3
Formal charge: 0

via PubChem

Drug data · ChEMBL

Withdrawn

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 1986
Indications: cardiac arrhythmia

via ChEMBL · EBI

Research

454 papers

Encainide.Cardiovascular drugs and therapy · 1989
Mortality and morbidity in patients receiving encainide, flecainide, or placebo. The Cardiac Arrhythmia Suppression Trial.The New England journal of medicine · 1991
Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction.The New England journal of medicine · 1989
[Encainide].Medicina (Florence, Italy) · 1988
Encainide--an updated safety profile.Cardiovascular drugs and therapy · 1990

via PubMed

Wikidata facts

Subclass of: chemical compound
Mass: 352.215078
Has use: medication

Show 6 more facts

chemical formula: C₂₂H₂₈N₂O₂
medical condition treated: heart arrhythmia
World Health Organisation international non-proprietary name: encainide
canonical SMILES: CN1CCCCC1CCC2=CC=CC=C2NC(=O)C3=CC=C(C=C3)OC
defined daily dose: 0.1
Commons category: Encainide

Sources (3)

via Wikidata · CC0

Article · Italiano

L'encainide è uno dei farmaci antiaritmici del gruppo IC, che aveva trovato impiego nella terapia delle aritmie ventricolari e sopraventricolari, in particolare nella Sindrome di Wolff-Parkinson-White.

Abstract from DBpedia / Wikipedia · CC BY-SA

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