EPHB6

Also known as HEP, EPH receptor B6

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

In the Vinony graph

Within Vinony's link graph, EPHB6 is referenced by 116 other articles, and connects out to PubMed, human chromosome 7 and Ensembl genome database project.

It sits within the topics Genes on human chromosome 7 and Tyrosine kinase receptors.

Its subject is documented across 6 Wikipedia language editions.

Gene data

EPHB6

Name: EPH receptor B6
Type: protein-coding
Position: 142,854,809–142,872,810 (+)
Aliases: HEP
Ensembl: ENSG00000106123
RefSeq RNA: NM_001280794.3, NM_001280795.2, NM_004445.6, NR_104001.2, XM_011515879.2
RefSeq protein: NP_001267723.2, NP_001267724.2, NP_004436.4, XP_011514181.1, XP_011514182.1

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

Gene Ontology

Biological process

cell surface receptor protein tyrosine kinase signaling pathway axon guidance ephrin receptor signaling pathway

Molecular function

protein kinase activity protein kinase activity ephrin receptor activity transmembrane-ephrin receptor activity protein binding ATP binding ATP binding signaling receptor activity

Cellular component

extracellular region extracellular region cytosol plasma membrane plasma membrane plasma membrane membrane dendrite

Pathways

Axon guidance - Homo sapiens (human)Developmental Biology Developmental Biology EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells

via MyGene.info

Gene · Ensembl

EPH receptor B6

Symbol: EPHB6
Biotype: Protein coding
Organism: Homo sapiens
Location: 7:142,854,809-142,872,810
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene

Show 8 more facts

HomoloGene ID: 20940
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2051
chromosome: human chromosome 7
genomic start: 142552792
genomic end: 142568847
cytogenetic location: 7q34
expressed in: prefrontal cortex

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene.

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.

Excerpted from Wikipedia’s “EPHB6” article, available under the CC BY-SA 4.0 licence.