Structure via PubChem · Public domain (PubChem)
اواستراپیب
Sign in to saveEvacetrapib was a drug under development by Eli Lilly and Company (investigational name LY2484595) that inhibits cholesterylester transfer protein (CETP inhibitor). CETP collects triglycerides from very low-density lipoproteins (VLDL) or low-density lipoproteins (LDL) and exchanges them for cholesteryl esters from high-density lipoproteins (HDL), and vice versa, but primarily increasing high-density lipoprotein and lowering low-density lipoprotein. It is thought that modifying lipoprotein levels modifies the risk of cardiovascular disease. The first CETP inhibitor, torcetrapib, was unsuccessfu
Chemical data
- Formula
- C31H36F6N6O2
- Molecular weight
- 638.6 g/mol
- IUPAC name
- 4-[[(5S)-5-[[3,5-bis(trifluoromethyl)phenyl]methyl-(2-methyltetrazol-5-yl)amino]-7,9-dimethyl-2,3,4,5-tetrahydro-1-benzazepin-1-yl]methyl]cyclohexane-1-carboxylic acid
- SMILES
- CC1=CC(=C2C(=C1)[C@H](CCCN2CC3CCC(CC3)C(=O)O)N(CC4=CC(=CC(=C4)C(F)(F)F)C(F)(F)F)C5=NN(N=N5)C)C
- InChIKey
- IHIUGIVXARLYHP-UXNJHFGPSA-N
- XLogP
- 7.7
- Polar surface area
- 87.4 Ų
- H-bond donors
- 1
- H-bond acceptors
- 13
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 3
- Molecule type
- Small molecule
- Indications
- cardiovascular disease, Disorder of lipid metabolism, Hypercholesterolemia, hyperlipidemia
via ChEMBL · EBI
Research
133 papers- Evacetrapib and Cardiovascular Outcomes in High-Risk Vascular Disease.The New England journal of medicine · 2017
- Evacetrapib.Current cardiology reports · 2012
- Evacetrapib: Another CETP Inhibitor for Dyslipidemia With No Clinical Benefit.Cardiology in review · 2017
- Safety and Efficacy of Evacetrapib in Patients with Inadequately-controlled Hypercholesterolemia and High Cardiovascular Risk; A meta-analysis of Randomized Placebo-controlled Trials.Prostaglandins, leukotrienes, and essential fatty acids · 2021
- CETP inhibitor evacetrapib enters mouse brain tissue.Frontiers in pharmacology · 2023
via PubMed
Wikidata facts
- Subclass of
- carboxylic acid
- Mass
- 638.280394
Show 3 more facts
- isomeric SMILES
- OC(=O)C1CCC(CC1)CN2CCC[C@@H](C3=C2C(C)=CC(=C3)C)N(C=4N=NN(N4)C)CC5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F
- canonical SMILES
- OC(=O)C1CCC(CC1)CN2CCCC(C3=C2C(C)=CC(=C3)C)N(C=4N=NN(N4)C)CC5=CC(=CC(=C5)C(F)(F)F)C(F)(F)F
- chemical formula
- C₃₁H₃₆F₆N₆O₂
Sources (1)
via Wikidata · CC0