エゼチミブ

Key facts

Drug.Watchedfields

changed

Drug.verifiedrevid

461098524

Drug.image

Ezetimibe.svg

Drug.image_class

skin-invert-image

Drug.caption

Above: molecular structure of ezetimibe Below: 3D representation of an ezetimibe molecule

Drug.image2

Ezetimibe 3D.png

Drug.image_class2

bg-transparent

Drug.tradename

Zetia, others

Drug.MedlinePlus

a603015

Drug.DailyMedID

Ezetimibe

Drug.pregnancy_AU

B3

Drug.routes_of_administration

By mouth

Drug.class

Cholesterol absorption inhibitor

Drug.ATC_prefix

C10

Drug.ATC_suffix

AX09

Drug.legal_AU

S4

Drug.legal_CA

Rx-only

Drug.legal_UK

POM

via Wikipedia infobox

Chemical data

Formula

C24H21F2NO3

Molecular weight

409.4 g/mol

IUPAC name

(3R,4S)-1-(4-fluorophenyl)-3-[(3S)-3-(4-fluorophenyl)-3-hydroxypropyl]-4-(4-hydroxyphenyl)azetidin-2-one

SMILES

C1=CC(=CC=C1[C@@H]2[C@H](C(=O)N2C3=CC=C(C=C3)F)CC[C@@H](C4=CC=C(C=C4)F)O)O

InChIKey

OLNTVTPDXPETLC-XPWALMASSA-N

XLogP

4

Polar surface area

60.8 Ų

H-bond donors

2

H-bond acceptors

5

Formal charge

0

via PubChem

Drug data · ChEMBL

Max clinical phase

Approved

Molecule type

Small molecule

First approval

2002

Admin. routes

oral

Indications

Hypercholesterolemia, metabolic syndrome, Disorder of lipid metabolism, chronic hepatitis C virus infection

via ChEMBL · EBI

• Rosuvastatin/Ezetimibe: A Review in Hypercholesterolemia.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2020
• Ezetimibe: a review of its metabolism, pharmacokinetics and drug interactions.Clinical pharmacokinetics · 2005
• Ezetimibe.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2003
• Ezetimibe.Expert opinion on investigational drugs · 2002
• Ezetimibe/simvastatin.Expert opinion on drug safety · 2009

via PubMed

Wikidata facts

Mass

409.14895

Has use

medication

via Wikidata · CC0