Structure via PubChem · Public domain (PubChem)
fenquizone
Sign in to saveFenquizone (INN) is a diuretic, part of the class of low-ceiling sulfonamide diuretics. Fenquizone is used primarily in the treatment of oedema and hypertension.
Chemical data
- Formula
- C14H12ClN3O3S
- Molecular weight
- 337.8 g/mol
- IUPAC name
- 7-chloro-4-oxo-2-phenyl-2,3-dihydro-1H-quinazoline-6-sulfonamide
- SMILES
- C1=CC=C(C=C1)C2NC3=CC(=C(C=C3C(=O)N2)S(=O)(=O)N)Cl
- InChIKey
- DBDTUXMDTSTPQZ-UHFFFAOYSA-N
- XLogP
- 1.8
- Polar surface area
- 110 Ų
- H-bond donors
- 3
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
- Indications
- cardiovascular disease
via ChEMBL · EBI
Research
15 papers- Single-dose pharmacokinetics of fenquizone in healthy volunteers.Arzneimittel-Forschung · 1985
- On the pharmacological actions of a diuretic, fenquizone, with particular reference to its site of action.The Journal of pharmacy and pharmacology · 1981
- Clinical pharmacokinetics of some newer diuretics.Clinical pharmacokinetics · 1987
- [Fenquizone in the medium term treatment of essential hypertension. Double-blind comparison with chlorthalidone and placebo].Minerva medica · 1981
- Gas-liquid chromatographic evaluation of fenquizone in biological samples for pharmacokinetic investigations.Journal of chromatography · 1983
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 337.029
Show 4 more facts
- Commons category
- Fenquizone
- chemical formula
- C₁₄H₁₂ClN₃O₃S
- canonical SMILES
- C1=CC=C(C=C1)C2NC3=CC(=C(C=C3C(=O)N2)S(=O)(=O)N)Cl
- subject has role
- diuretic
Sources (2)
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Fenquizone (INN) is a diuretic, part of the class of low-ceiling sulfonamide diuretics. Fenquizone is used primarily in the treatment of oedema and hypertension.
==See also== Quinethazone Metolazone
Excerpted from Wikipedia’s “fenquizone” article, available under the CC BY-SA 4.0 licence.