Structure via PubChem · Public domain (PubChem)
Chemical data
- Formula
- C15H14FN3O3
- Molecular weight
- 303.29 g/mol
- IUPAC name
- ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
- SMILES
- CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
- InChIKey
- OFBIFZUFASYYRE-UHFFFAOYSA-N
- XLogP
- 1
- Polar surface area
- 64.4 Ų
- H-bond donors
- 0
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1991
- Admin. routes
- parenteral
- Indications
- insomnia, obsessive-compulsive disorder, drug dependence, anxiety
via ChEMBL · EBI
Research
5,183 papers- [Flumazenil].Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology · 2014
- Flumazenil--treatment or toxin.Journal of toxicology. Clinical toxicology · 2004
- Flumazenil.Lancet (London, England) · 1988
- Flumazenil: a benzodiazepine antagonist.Clinical pharmacy · 1993
- Flumazenil.British journal of hospital medicine · 1994
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 303.10192
- Has use
- medication
Show 6 more facts
- commercialization date
- 1987-00-00
- chemical formula
- C₁₅H₁₄FN₃O₃
- canonical SMILES
- CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
- World Health Organisation international non-proprietary name
- flumazenil
- Commons category
- Flumazenil
- legal status (medicine)
- boxed warning
via Wikidata · CC0
~7 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- PET radioligand
- Treatment for benzodiazepine dependence & tolerance
- Pharmacology
- Pharmacodynamics
- Availability
- References
- External links
thumb|A vial of flumazenil solution for injection
Flumazenil, also known as flumazepil, is a selective GABAA receptor antagonist administered via injection, or intranasally. Therapeutically, it acts as both an antagonist and antidote to benzodiazepines (particularly in cases of overdose), through competitive inhibition.
Excerpted from Wikipedia’s “flumazenil” article, available under the CC BY-SA 4.0 licence.