flumazenil

Also known as flumazepil

thumb|A vial of flumazenil solution for injection

Chemical data

Formula: C15H14FN3O3
Molecular weight: 303.29 g/mol
IUPAC name: ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
SMILES: CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
InChIKey: OFBIFZUFASYYRE-UHFFFAOYSA-N
XLogP: 1
Polar surface area: 64.4 Å²
H-bond donors: 0
H-bond acceptors: 5
Formal charge: 0

via PubChem

Research

5,183 papers

[Flumazenil].Chudoku kenkyu : Chudoku Kenkyukai jun kikanshi = The Japanese journal of toxicology · 2014
Flumazenil--treatment or toxin.Journal of toxicology. Clinical toxicology · 2004
Flumazenil.Lancet (London, England) · 1988
Flumazenil: a benzodiazepine antagonist.Clinical pharmacy · 1993
Flumazenil.British journal of hospital medicine · 1994

via PubMed

Wikidata facts

Mass: 303.10192

Show 5 more facts

commercialization date: 1987-00-00
chemical formula: C₁₅H₁₄FN₃O₃
canonical SMILES: CCOC(=O)C1=C2CN(C(=O)C3=C(N2C=N1)C=CC(=C3)F)C
World Health Organisation international non-proprietary name: flumazenil
Commons category: Flumazenil

Sources (4)

via Wikidata · CC0

~7 min read

Article

8 sections

Contents

Medical uses
PET radioligand
Treatment for benzodiazepine dependence & tolerance
Pharmacology
Pharmacodynamics
Availability
References
External links

thumb|A vial of flumazenil solution for injection

Flumazenil, also known as flumazepil, is a selective GABAA receptor antagonist administered via injection, or intranasally. Therapeutically, it acts as both an antagonist and antidote to benzodiazepines (particularly in cases of overdose), through competitive inhibition.