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GeneQ17916513· pop 5· linked from 813 articles

ELF5

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Also known as ESE2, E74 like ETS transcription factor 5

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans. In humans it is also called ESE2.

In the Vinony graph

Vinony's link graph records 813 inbound references to ELF5, and connects out to PubMed, human chromosome 11 and homeobox.

Vinony files it under Genes on human chromosome 11 and Transcription factors.

Vinony links it to 5 Wikipedia language editions.

Gene data

ELF5

Name: E74 like ETS transcription factor 5
Type: protein-coding
Position: 34,478,791–34,525,193 (−)
Aliases: ESE2
Ensembl: ENSG00000135374
RefSeq RNA: NM_001243080.2, NM_001243081.2, NM_001422.4, NM_198381.2, XM_017017308.2
RefSeq protein: NP_001230009.1, NP_001230010.1, NP_001413.1, NP_938195.1, XP_016872797.1

This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast cancer. [provided by RefSeq, May 2022].

Gene Ontology

Biological process

regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell differentiation positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity protein binding sequence-specific DNA binding sequence-specific double-stranded DNA binding

Cellular component

chromatin nucleus nucleus cytoplasm

Pathways

Prolactin signaling pathway - Homo sapiens (human)Developmental Biology Developmental Cell Lineages Developmental Cell Lineages of the Integumentary System Developmental Lineages of the Mammary Gland Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Alveolar Cells Mammary gland development pathway - Pregnancy and lactation (Stage 3 of 4)

via MyGene.info

Gene · Ensembl

E74 like ETS transcription factor 5

Symbol: ELF5
Biotype: Protein coding
Organism: Homo sapiens
Location: 11:34,478,791-34,525,193
Strand: Reverse (−)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein ELF5 PDB 1wwx.png

Show 7 more facts

HomoloGene ID: 7702
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/2001
genomic end: 34525193
genomic start: 34478791
chromosome: human chromosome 11
cytogenetic location: 11p13

Sources (4)

via Wikidata · CC0

~1 min read

Encyclopedic overview

5 sections

Contents

Function
Relevance to Disease
References
Further reading
External links

E74-like factor 5 (ets domain transcription factor), is a gene found in both mice and humans. In humans it is also called ESE2.

== Function ==

Excerpted from Wikipedia’s “ELF5” article, available under the CC BY-SA 4.0 licence.

Available in 5 languages

via Wikidata sitelinks · CC0

Categories

Genes on human chromosome 11 Transcription factors