Structure via PubChem · Public domain (PubChem)
gilteritinib
Sign in to saveAlso known as ASP-2215, ASP2215
Gilteritinib, sold under the brand name Xospata, is an anti-cancer drug.
Chemical data
- Formula
- C29H44N8O3
- Molecular weight
- 552.7 g/mol
- IUPAC name
- 6-ethyl-3-[3-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]anilino]-5-(oxan-4-ylamino)pyrazine-2-carboxamide
- SMILES
- CCC1=C(N=C(C(=N1)C(=O)N)NC2=CC(=C(C=C2)N3CCC(CC3)N4CCN(CC4)C)OC)NC5CCOCC5
- InChIKey
- GYQYAJJFPNQOOW-UHFFFAOYSA-N
- XLogP
- 3.5
- Polar surface area
- 121 Ų
- H-bond donors
- 3
- H-bond acceptors
- 10
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2018
- Admin. routes
- oral
- Indications
- neoplasm, acute myeloid leukemia, liver disease, non-small cell lung carcinoma
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 552.353637
- Has use
- medication
Show 6 more facts
- canonical SMILES
- CCC1=NC(=C(N=C1NC2CCOCC2)NC3=CC(=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)OC)C(=O)N
- chemical formula
- C₂₉H₄₄N₈O₃
- Commons category
- Gilteritinib
- legal status (medicine)
- boxed warning
- subject has role
- protein kinase inhibitors
- medical condition treated
- acute myeloid leukemia
Sources (6)
via Wikidata · CC0
~1 min read
Encyclopedic overview
5 sectionsContents
- Mechanism of action
- History
- References
- Further reading
- External links
Gilteritinib, sold under the brand name Xospata, is an anti-cancer drug.
==Mechanism of action== Gilteritinib acts as an inhibitor of FLT3, hence it is a tyrosine kinase inhibitor.
Excerpted from Wikipedia’s “gilteritinib” article, available under the CC BY-SA 4.0 licence.