glycylcycline
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Glycylcyclines are a class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance, namely resistance mediated by acquired efflux pumps and/or ribosomal protection. Presently, tigecycline is the only glycylcycline approved for antibiotic use.
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Within Vinony's link graph, glycylcycline is referenced by 126 other articles, and connects out to neomycin, antibiotic and digital object identifier.
Vinony files it under Glycylcycline antibiotics and Tetracyclic compounds.
Its subject is documented across 9 Wikipedia language editions.
Wikidata facts
- Instance of
- drug class
- Subclass of
- tetracycline antibiotic
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- Category:Glycylcycline antibiotics
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Encyclopedic overview
7 sectionsContents
- History
- Approvals
- Mechanism of action
- Mechanisms of resistance
- Side effects and contraindications
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Glycylcyclines are a class of antibiotics derived from tetracycline. These tetracycline analogues are specifically designed to overcome two common mechanisms of tetracycline resistance, namely resistance mediated by acquired efflux pumps and/or ribosomal protection. Presently, tigecycline is the only glycylcycline approved for antibiotic use.
== History == The development of these agents was spurred by the increasing prevalence of bacteria resistant to tetracyclines. These agents were first synthesized in the early 1990s by making modifications to the tetracyclines. By adding a bulky N,N-dimethylglycylamido side chain to position 9 of minocycline, the compound became less susceptible to tetracycline resistance mediated by acquired efflux pumps and/or ribosomal protection. Further development of this initial work led to the creation of tigecycline, the first glycylcycline available for clinical use.
Excerpted from Wikipedia’s “glycylcycline” article, available under the CC BY-SA 4.0 licence.
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