H1-4

Also known as histone cluster 1, H1e, H1.4, H1E, H1F4, H1s-4, dJ221C16.5, histone cluster 1 H1 family member e, RMNS

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.

Gene data

H1-4

Name: H1.4 linker histone, cluster member
Type: protein-coding
Aliases: H1.4, H1E, H1F4, H1s-4, HIST1H1E, RMNS, dJ221C16.5

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015].

via MyGene.info

Gene · Ensembl

H1.4 linker histone, cluster member

Symbol: H1-4
Biotype: Protein coding
Organism: Homo sapiens
Location: 6:26,156,329-26,157,115
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Image: Cryo-EM structure of FoxA1 and GATA4 in complex with H14 chromatosome Histone H1.4 (2) 8VG2.png

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HomoloGene ID: 130534
exact match: identifiers.org/ncbigene/3008
genomic end: 26157115
genomic start: 26156329
cytogenetic location: 6p22.2

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HIST1H1E syndrome
References
Further reading

Histone H1.4 is a protein that in humans is encoded by the HIST1H1E gene.

Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6.