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hexamethonium
Sign in to saveAlso known as N,N,N,N',N',N'-hexamethylhexane-1,6-diaminium
Hexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system, nor on the nicotinic receptors at the skeletal neuromuscular junction, but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (nAChR).
Chemical data
- Formula
- C12H30N2+2
- Molecular weight
- 202.38 g/mol
- IUPAC name
- trimethyl-[6-(trimethylazaniumyl)hexyl]azanium
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Phase 2
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
7,440 papers- Hexamethonium bromide.Lancet (London, England) · 1950
- [Hexamethonium].Wiener Zeitschrift fur innere Medizin und ihre Grenzgebiete · 1953
- Fibrous healing of old iatrogenic pulmonary edema ("hexamethonium lung").The Journal of pathology and bacteriology · 1962
- Hexamethonium and glaucoma.The British journal of ophthalmology · 1952
- Hexamethonium-induced hypotension.Minnesota medicine · 1955
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 202.23980180017998
Show 4 more facts
- canonical SMILES
- C[N+](C)(C)CCCCCC[N+](C)(C)C
- subject has role
- nicotinic antagonist
- Commons category
- Hexamethonium
- chemical formula
- C₁₂H₃₀N₂²⁺
via Wikidata · CC0
~2 min read
Encyclopedic overview
4 sectionsContents
- Pharmacology
- Uses
- See also
- References
Hexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system, nor on the nicotinic receptors at the skeletal neuromuscular junction, but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (nAChR).
== Pharmacology ==
Excerpted from Wikipedia’s “hexamethonium” article, available under the CC BY-SA 4.0 licence.