hexamethonium
Sign in to saveHexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system, nor on the nicotinic receptors at the skeletal neuromuscular junction, but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (nAChR).
Chemical data
- Formula
- C12H30N2+2
- Molecular weight
- 202.38 g/mol
- IUPAC name
- trimethyl-[6-(trimethylazaniumyl)hexyl]azanium
via PubChem
Wikidata facts
- Subclass of
- chemical compound
- Mass
- +202.23980180017998
Show 1 more fact
- P2868
- nicotinic antagonist
via Wikidata · CC0
Article
4 sectionsContents
- Pharmacology
- Uses
- See also
- References
Hexamethonium is a non-depolarising ganglionic blocker, a neuronal nicotinic (nAChR) receptor antagonist that acts in autonomic ganglia by binding mostly in or on the nAChR receptor, and not the acetylcholine binding site itself. It does not have any effect on the muscarinic acetylcholine receptors (mAChR) located on target organs of the parasympathetic nervous system, nor on the nicotinic receptors at the skeletal neuromuscular junction, but acts as antagonist at the nicotinic acetylcholine receptors located in sympathetic and parasympathetic ganglia (nAChR).
== Pharmacology ==