chlorphenoxamine

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is an analog of diphenhydramine.

In the Vinony graph

Within Vinony's link graph, chlorphenoxamine is referenced by 421 other articles, and connects out to atropine, histamine antagonist and nicotinic acetylcholine receptor.

It is catalogued under topics including 4-Chlorophenyl compounds, Dimethylamino compounds and Drugboxes which contain changes to verified fields.

Its subject is documented across 9 Wikipedia language editions.

Research

37 papers

Novel RP-HPLC-DAD approach for simultaneous determination of chlorphenoxamine hydrochloride and caffeine with their related substances.BMC chemistry · 2024
Urinary metabolism of chlorphenoxamine in man.Arzneimittel-Forschung · 1987
Chlorphenoxamine hydrochloride in parkinsonism. A controlled trial.British medical journal · 1961
Smart green spectrophotometric estimation and content uniformity testing of chlorphenoxamine HCl and caffeine in bulk forms and combined pharmaceutical formulation.Scientific reports · 2025
[Isolation of chlorphenoxamine metabolites in human urine and their identification].Arzneimittel-Forschung · 1987

via PubMed

Wikidata facts

Mass: 303.139

Show 3 more facts

chemical formula: C₁₈H₂₂ClNO
defined daily dose: 80
canonical SMILES: CC(C1=CC=CC=C1)(C2=CC=C(C=C2)Cl)OCCN(C)C

Sources (3)

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Encyclopedic overview

1 sections

Contents

References

{{Drugbox |Verifiedfields = changed |Watchedfields = changed |verifiedrevid = 447811372 |IUPAC_name = {2-[1-(4-chlorophenyl)-1-phenylethoxy]ethyl}dimethylamine |image = Chlorphenoxamine.svg |image_class = skin-invert-image |Drugs.com = |routes_of_administration = Oral, topical |bioavailability = Well absorbed |metabolism = Likely liver |excretion = kidney |CAS_number_Ref = |CAS_number = 77-38-3 |CAS_supplemental = |ATC_prefix = D04 |ATC_suffix = AA34 |ATC_supplemental = |PubChem = 6475 |DrugBank_Ref = |DrugBank = DB09007 |ChemSpiderID_Ref = |ChemSpiderID = 6230 |ChEMBL_Ref = |ChEMBL = 2110774 |UNII_Ref = |UNII = 3UVD77BP8R |KEGG_Ref = |KEGG = D07198 |C=18 | H=22 | Cl=1 | N=1 | O=1 |smiles = Clc1ccc(cc1)C(OCCN(C)C)(c2ccccc2)C |StdInChI_Ref = |StdInChI = 1S/C18H22ClNO/c1-18(21-14-13-20(2)3,15-7-5-4-6-8-15)16-9-11-17(19)12-10-16/h4-12H,13-14H2,1-3H3 |StdInChIKey_Ref = |StdInChIKey = KKHPNPMTPORSQE-UHFFFAOYSA-N }}

Chlorphenoxamine (Phenoxene) is an antihistamine and anticholinergic used as an antipruritic and antiparkinsonian agent. It is an analog of diphenhydramine.

Excerpted from Wikipedia’s “chlorphenoxamine” article, available under the CC BY-SA 4.0 licence.