HGFAC

Also known as HGFA, HGF activator

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.

In the Vinony graph

Vinony's link graph records 6 inbound references to HGFAC, and connects out to PubMed, human chromosome 4 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 4.

Vinony links it to 5 Wikipedia language editions.

Gene data

HGFAC

Name: HGF activator
Type: protein-coding
Position: 3,441,924–3,449,493 (+)
Aliases: HGFA
Ensembl: ENSG00000109758
RefSeq RNA: NM_001297439.2, NM_001528.4, XM_047450155.1, XM_054349861.1
RefSeq protein: NP_001284368.1, NP_001519.1, XP_047306111.1, XP_054205836.1

This gene encodes a member of the peptidase S1 protein family. The encoded protein is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Gene Ontology

Biological process

proteolysis proteolysis blood coagulation zymogen activation

Molecular function

serine-type endopeptidase activity serine-type endopeptidase activity serine-type endopeptidase activity protein binding serine-type peptidase activity

Cellular component

extracellular region extracellular region extracellular region extracellular region extracellular region cytoplasm rough endoplasmic reticulum rough endoplasmic reticulum

Pathways

Signal Transduction Signaling by MET MET Receptor Activation Signaling by Receptor Tyrosine Kinases

via MyGene.info

Gene · Ensembl

HGF activator

Symbol: HGFAC
Biotype: Protein coding
Organism: Homo sapiens
Location: 4:3,441,924-3,449,493
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Protein HGFAC PDB 1ybw.png

Show 8 more facts

HomoloGene ID: 1170
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/3083
genomic end: 3449486
genomic start: 3441968
chromosome: human chromosome 4
cytogenetic location: 4p16.3
expressed in: anterior pituitary

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene.

The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.

Excerpted from Wikipedia’s “HGFAC” article, available under the CC BY-SA 4.0 licence.