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AI overview
Histones are proteins found in the nuclei of eukaryotic cells that act as spools around which DNA winds, helping to organize and protect the genetic material. They are essential for preventing DNA from becoming tangled, shielding it from damage, and controlling which genes are turned on or off in cells.
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Research
160,348 papers- Lateral Thinking: How Histone Modifications Regulate Gene Expression.ReviewTrends in genetics : TIG · 2016Lawrence M, Daujat S, Schneider RDOI: 10.1016/j.tig.2015.10.007
- Erasers of histone acetylation: the histone deacetylase enzymes.ReviewCold Spring Harbor perspectives in biology · 2014Seto E, Yoshida MDOI: 10.1101/cshperspect.a018713
- Histone variants at a glance.ReviewJournal of cell science · 2021Talbert PB, Henikoff SDOI: 10.1242/jcs.244749
- Histone variants: The bricks that fit differently.ReviewThe Journal of biological chemistry · 2025Hegazy YA, Dhahri H, El Osmani N et al.DOI: 10.1016/j.jbc.2024.108048
- Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis.EMBO reports · 2021Yang G, Yuan Y, Yuan H et al.DOI: 10.15252/embr.202050967
- H3-H4 histone chaperones and cancer.ReviewCurrent opinion in genetics & development · 2022Ray-Gallet D, Almouzni GDOI: 10.1016/j.gde.2022.101900
- Histone degradation by the proteasome regulates chromatin and cellular plasticity.ReviewThe FEBS journal · 2022Shmueli MD, Sheban D, Eisenberg-Lerner A et al.DOI: 10.1111/febs.15903
- Primate-specific histone variants.ReviewGenome · 2021Ding D, Nguyen TT, Pang MYH et al.DOI: 10.1139/gen-2020-0094
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