RNASEH2C
Sign in to saveAlso known as AGS3, AYP1, ribonuclease H2 subunit C
Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C), and degrades the RNA of RNA:DNA hybrids.
In the Vinony graph
Within Vinony's link graph, RNASEH2C is referenced by 451 other articles, and connects out to PubMed, human chromosome 11 and Ensembl genome database project.
It is catalogued under the topic Genes on human chromosome 11.
Its subject is documented across 5 Wikipedia language editions.
Gene data
RNASEH2C- Name
- ribonuclease H2 subunit C
- Type
- protein-coding
- Position
- 65,713,901–65,720,988 (−)
- Aliases
- AGS3, AYP1
- Ensembl
- ENSG00000172922
- RefSeq RNA
- NM_032193.4
- RefSeq protein
- NP_115569.2
This gene encodes a ribonuclease H subunit that can cleave ribonucleotides from RNA:DNA duplexes. Mutations in this gene cause Aicardi-Goutieres syndrome-3, a disease that causes severe neurologic dysfunction. A pseudogene for this gene has been identified on chromosome Y, near the sex determining region Y (SRY) gene. [provided by RefSeq, Jul 2008].
Gene Ontology
Molecular function
via MyGene.info
Gene · Ensembl
ribonuclease H2 subunit C
- Symbol
- RNASEH2C
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 11:65,713,901-65,720,988
- Strand
- Reverse (−)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- 3puf highlight subunit C.png
Show 8 more facts
- HomoloGene ID
- 32666
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/84153
- genomic end
- 65720818
- genomic start
- 65714005
- chromosome
- human chromosome 11
- cytogenetic location
- 11q13.1
- genetic association
- Aicardi-Goutieres syndrome
via Wikidata · CC0
~1 min read
Encyclopedic overview
4 sectionsContents
- Function
- References
- Further reading
- External links
Ribonuclease H2 subunit C is a protein that in humans is encoded by the RNASEH2C gene. RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C), and degrades the RNA of RNA:DNA hybrids.
Mutations in this gene are a cause of Aicardi-Goutieres syndrome type 3 (AGS3).
Excerpted from Wikipedia’s “RNASEH2C” article, available under the CC BY-SA 4.0 licence.