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GeneQ18027448· pop 8· linked from 1,854 articles

HTR6

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Also known as 5-HT6, 5-HT6R, 5-HT6 receptor, 5-hydroxytryptamine receptor 6

protein-coding gene in the species Homo sapiens

Gene data

HTR6

Name: 5-hydroxytryptamine receptor 6
Type: protein-coding
Position: 19,664,875–19,680,966 (+)
Aliases: 5-HT6, 5-HT6R
Ensembl: ENSG00000158748
RefSeq RNA: NM_000871.3
RefSeq protein: NP_000862.1

This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013].

Gene Ontology

Biological process

G protein-coupled receptor signaling pathway G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger adenylate cyclase-modulating G protein-coupled receptor signaling pathway adenylate cyclase-activating serotonin receptor signaling pathway chemical synaptic transmission chemical synaptic transmission positive regulation of cell communication

Molecular function

G protein-coupled receptor activity histamine receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity G protein-coupled serotonin receptor activity protein binding neurotransmitter receptor activity

Cellular component

plasma membrane plasma membrane plasma membrane plasma membrane cilium membrane dendrite synapse

Pathways

Calcium signaling pathway - Homo sapiens (human)cAMP signaling pathway - Homo sapiens (human)Neuroactive ligand-receptor interaction - Homo sapiens (human)Serotonergic synapse - Homo sapiens (human)Signal Transduction Signaling by GPCR Class A/1 (Rhodopsin-like receptors)Amine ligand-binding receptors GPCR downstream signalling Serotonin receptors

via MyGene.info

Wikidata facts

Show 5 more facts

HomoloGene ID: 673
exact match: identifiers.org/ncbigene/3362
genomic end: 19680966
genomic start: 19664875
cytogenetic location: 1p36.13

Sources (5)

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Categories

Genes on human chromosome 1 Serotonin receptors