ISG20
Sign in to saveAlso known as CD25, HEM45, interferon stimulated exonuclease gene 20kDa, interferon stimulated exonuclease gene 20
Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene. It belongs to the ISG family of proteins, which are typically stimulated by type I interferon as a response to viral infection.
Gene data
ISG20- Name
- interferon stimulated exonuclease gene 20
- Type
- protein-coding
- Position
- 88,635,618–88,656,483 (+)
- Aliases
- CD25, HEM45
- Ensembl
- ENSG00000172183
- RefSeq RNA
- NM_001303233.2, NM_001303234.2, NM_001303235.2, NM_001303236.2, NM_001303237.2
- RefSeq protein
- NP_001290162.1, NP_001290163.1, NP_001290164.1, NP_001290165.1, NP_001290166.1
Enables 3'-5' exonuclease activity and RNA binding activity. Involved in defense response to virus; negative regulation of viral genome replication; and nucleobase-containing compound catabolic process. Located in cytoplasm and nuclear lumen. [provided by Alliance of Genome Resources, Apr 2022]
Gene Ontology
Biological process
Molecular function
via MyGene.info
Wikidata facts
- Image
- Protein ISG20 PDB 1wlj.png
Show 5 more facts
- HomoloGene ID
- 31081
- exact match
- identifiers.org/ncbigene/3669
- genomic end
- 89199714
- genomic start
- 88635670
- cytogenetic location
- 15q26.1
Sources (4)
via Wikidata · CC0
~2 min read
Article
6 sectionsContents
- Discovery
- Structure
- Function
- Clinical significance
- References
- Further reading
Interferon-stimulated gene 20 kDa protein is a protein that in humans is encoded by the ISG20 gene. It belongs to the ISG family of proteins, which are typically stimulated by type I interferon as a response to viral infection.
==Discovery== ISG20 was discovered in 1997 at the Institute for Molecular Genetics (IGMM) within the University of Montpellier. The new protein was discovered through differential display in IFNα/β treated human cells.