IFI16
Sign in to saveAlso known as IFNGIP1, PYHIN2, interferon gamma inducible protein 16
Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.
Gene data
IFI16- Name
- interferon gamma inducible protein 16
- Type
- protein-coding
- Aliases
- IFNGIP1, PYHIN2
This gene encodes a member of the HIN-200 (hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats) family of cytokines. The encoded protein contains domains involved in DNA binding, transcriptional regulation, and protein-protein interactions. The protein localizes to the nucleoplasm and nucleoli, and interacts with p53 and retinoblastoma-1. It modulates p53 function, and inhibits cell growth in the Ras/Raf signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011].
via MyGene.info
Gene · Ensembl
interferon gamma inducible protein 16
- Symbol
- IFI16
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 1:158,999,938-159,055,156
- Strand
- Forward (+)
- Assembly
- GRCh38
via Ensembl · EMBL-EBI
Wikidata facts
- Image
- Protein IFI16 PDB 2oq0.png
Show 5 more facts
- HomoloGene ID
- 115929
- genomic start
- 158969758
- exact match
- identifiers.org/ncbigene/3428
- genomic end
- 159024945
- cytogenetic location
- 1q23.1
via Wikidata · CC0
~1 min read
Article
4 sectionsContents
- Function
- References
- Further reading
- External links
Gamma-interferon-inducible protein Ifi-16 (Ifi-16) also known as interferon-inducible myeloid differentiation transcriptional activator is a protein that in humans is encoded by the IFI16 gene.
== Function ==