isoconazole
Sign in to saveAlso known as R-15454 [as nitrate salt]
Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria. For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.
Key facts
- Drug.IUPAC_name
- (RS)-1-[2-[(2,6-Dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole
- Drug.image
- Isoconazole.svg
- Drug.image_class
- skin-invert-image
- Drug.CAS_number
- 27523-40-6
- Drug.ATC_prefix
- D01
- Drug.ATC_suffix
- AC05
- Drug.PubChem
- 3760
- Drug.DrugBank
- DB08943
- Drug.ChEMBL
- 1571863
- Drug.ChemSpiderID
- 3629
- Drug.UNII
- GRI7WFR424
- Drug.KEGG
- D04624
- Drug.ChEBI
- 82865
- Drug.C
- 18
- Drug.H
- 14
- Drug.Cl
- 4
- Drug.N
- 2
- Drug.O
- 1
via Wikipedia infobox
Research
159 papers- Otomycosis: Diagnosis and treatment.Clinics in dermatology · 2010
- Isoconazole nitrate: a unique broad-spectrum antimicrobial azole effective in the treatment of dermatomycoses, both as monotherapy and in combination with corticosteroids.Mycoses · 2013
- Structural and Spectroscopic Properties of Isoconazole and Bifonazole-Experimental and Theoretical Studies.International journal of molecular sciences · 2022
- Isoconazole and Clemizole Hydrochloride Partially Reverse the Xeroderma Pigmentosum C Phenotype.International journal of molecular sciences · 2021
- Treatment of angular cheilitis: A narrative review and authors' clinical experience.Oral diseases · 2020
via PubMed
Wikidata facts
- Mass
- 413.986023788
Show 4 more facts
- chemical formula
- C₁₈H₁₄Cl₄N₂O
- Commons category
- Isoconazole
- canonical SMILES
- C1=CC(=C(C(=C1)Cl)COC(CN2C=CN=C2)C3=C(C=C(C=C3)Cl)Cl)Cl
- defined daily dose
- 0.6
Sources (3)
via Wikidata · CC0
~1 min read
Article
1 sectionsContents
- References
Isoconazole is an azole antifungal drug and could inhibit gram positive bacteria. For foot and vaginal infections, isoconazole has a similar effectiveness to clotrimazole. Isoconazole nitrate may be used in combination with corticosteroid diflucortolone to increase its bioavailability.
It was patented in 1968 and approved for medical use in 1979.
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