異維A酸
Also known as Ro-43780, 13-RA, cis-RA, (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid, 13-cis-vitamin A acid, (7e,9e,11e,13Z)-retinoic acid, 13-cis-retinoic acid, cis-retinoic acid
Isotretinoin, also known as '13-cis-retinoic acid and sold under the brand name Accutane' among others, is a medication used to treat skin diseases like harlequin-type ichthyosis, lamellar ichthyosis, and severe cystic acne or moderate acne that is unresponsive to antibiotics. Isotretinoin is used off-label to treat basal cell carcinoma and squamous cell carcinoma, although clinical evidence suggests it is not effective in this setting. It is a retinoid, meaning it is related to vitamin A, and is found in small quantities naturally in the body. Its isomer, tretinoin, is also an acne drug. In i
Chemical data
- Formula
- C20H28O2
- Molecular weight
- 300.4 g/mol
- IUPAC name
- (2Z,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenoic acid
- SMILES
- CC1=C(C(CCC1)(C)C)/C=C/C(=C/C=C/C(=C\C(=O)O)/C)/C
- InChIKey
- SHGAZHPCJJPHSC-XFYACQKRSA-N
- XLogP
- 6.3
- Polar surface area
- 37.3 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Wikidata facts
- Mass
Article · 中文
異維A酸（Isotretinoin），是维A酸的异构体，最初是一種治療腦癌、胰臟癌和皮膚癌等多種癌病的藥物，但現時常用作治療青春痘，通常為口服用A酸，外用A酸則通常為維A酸成份，有時亦用作醫治斑色鱼鳞癣。它属于衍生自维生素A的，人体可自然形成小量的此化学物。 自2002年2月起，羅氏藥廠對異維A酸專利權屆滿後，市面有多間廠商生産通用名药物。其中中國商品名稱叫作「泰尔絲」或「特維絲」，其餘常見藥名包括Accutane、Amnesteem、Claravis、Decutan、Isotane、Sotret、Oratane、Isotrex和Isotrexin等。 異維A酸的副作用近年引起廣泛關注。有不同研究探討該藥是否會引致抑鬱，增加自殺風險。中国国家食品药品监督管理局亦警告該藥可能影響成長中的骨骼，建议18岁以下青少年尽量不要使用。孕婦服用後亦會大幅增加生出畸胎的機會，因而被绝对禁止使用。
Abstract from DBpedia / Wikipedia · CC BY-SA