Structure via PubChem · Public domain (PubChem)
isradipine
Sign in to saveAlso known as Dynacirc, PN-200-110, Dynacirc Cr, Isradipino, Isradipinum
Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.
Chemical data
- Formula
- C19H21N3O5
- Molecular weight
- 371.4 g/mol
- IUPAC name
- 3-O-methyl 5-O-propan-2-yl 4-(2,1,3-benzoxadiazol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
- InChIKey
- HMJIYCCIJYRONP-UHFFFAOYSA-N
- XLogP
- 4.3
- Polar surface area
- 104 Ų
- H-bond donors
- 1
- H-bond acceptors
- 8
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1990
- Admin. routes
- oral
- Indications
- cardiovascular disease, opioid dependence, hypertension, nicotine dependence
via ChEMBL · EBI
Research
1,742 papers- Applications of isradipine in human addiction studies: A systematic literature review.Experimental and clinical psychopharmacology · 2023
- Isradipine in hypertension.Drugs · 1990
- Isradipine plasma pharmacokinetics and exposure-response in early Parkinson's disease.Annals of clinical and translational neurology · 2021
- Isradipine. An update of its pharmacodynamic and pharmacokinetic properties and therapeutic efficacy in the treatment of mild to moderate hypertension.Drugs · 1995
- Isradipine--another calcium-channel blocker for the treatment of hypertension and angina.The Annals of pharmacotherapy · 1992
via PubMed
Wikidata facts
- Mass
- 371.148
- Has use
- medication
Show 6 more facts
- Commons category
- Isradipine
- defined daily dose
- 5
- chemical formula
- C₁₉H₂₁N₃O₅
- medical condition treated
- arterial hypertension
- canonical SMILES
- CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
- subject has role
- vasodilator agent
via Wikidata · CC0
~3 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Side effects
- Drug interactions
- Overdose
- Stereochemistry
- References
- Further reading
- External links
Isradipine (tradenames DynaCirc, Prescal) is a calcium channel blocker of the dihydropyridine class. It is usually prescribed for the treatment of high blood pressure in order to reduce the risk of stroke and heart attack.
It was patented in 1978 and approved for medical use in 1989.
Excerpted from Wikipedia’s “isradipine” article, available under the CC BY-SA 4.0 licence.