itopride
Sign in to saveItopride (INN; brand name Ganaton) is a prokinetic benzamide derivative. These drugs inhibit dopamine and acetylcholine esterase enzyme and have a gastrokinetic effect. Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. It is a combined D2 receptor antagonist and acetylcholinesterase inhibitor. Itopride is the dimethoxy analog of trimethobenzamide.
Key facts
- Drug.KEGG
- D08094
- Drug.KEGG2
- D02729
- Drug.Verifiedfields
- changed
- Drug.verifiedrevid
- 444538072
- Drug.image
- Itopride.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 260
- Drug.image2
- 3D Itopride.png
- Drug.image_class2
- bg-transparent
- Drug.tradename
- Ganaton
- Drug.legal_status
- Rx-only
- Drug.routes_of_administration
- By mouth
- Drug.ATC_prefix
- A03
- Drug.ATC_suffix
- FA07
- Drug.bioavailability
- ~60% (Tmax = 35±5 min)
- Drug.protein_bound
- 96%
- Drug.metabolism
- Extensive hepatic (FMO1 and FMO3), primarily N-oxidation
- Drug.elimination_half life
- 5.7±0.3 hours
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10 sectionsContents
- Medical uses
- Adverse drug reactions
- Cardiac studies
- Pharmacology
- Pharmacokinetics
- Mechanism of action
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Itopride (INN; brand name Ganaton) is a prokinetic benzamide derivative. These drugs inhibit dopamine and acetylcholine esterase enzyme and have a gastrokinetic effect. Itopride is indicated for the treatment of functional dyspepsia and other gastrointestinal conditions. It is a combined D2 receptor antagonist and acetylcholinesterase inhibitor. Itopride is the dimethoxy analog of trimethobenzamide.
==Medical uses== thumb|240px|A blister package of Ganaton (Itopride) 50 mg tablets intended for distribution in the Slovak Republic. Typically, itopride is indicated in the treatment of GI symptoms caused by reduced GI motility: dyspepsia of a non-ulcer/dysmotility type (gastric "fullness", discomfort, and possible pain) gastroparesis (delayed gastric emptying) anorexia heartburn regurgitation bloating nausea and vomiting other possible gastric, prolactin, or dopamine related conditions
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Acetylcholinesterase inhibitorsBenzamidesCatechol ethersChemical articles with multiple CAS registry numbersChemicals using indexlabelsD2 antagonistsDrugboxes which contain changes to verified fieldsDrugs developed by AbbVieDrugs developed by Takeda Pharmaceutical CompanyDrugs with non-standard legal statusECHA InfoCard ID from WikidataMotility stimulants