ITPR3
Sign in to saveAlso known as IP3R, IP3R3, inositol 1,4,5-trisphosphate receptor type 3
gene umano
Gene data
ITPR3- Name
- inositol 1,4,5-trisphosphate receptor type 3
- Type
- protein-coding
- Position
- 33,620,331–33,696,575 (+)
- Aliases
- CMT1J, IMD132, IMD133, IP3R, IP3R-3, IP3R3
- Ensembl
- ENSG00000096433
- RefSeq RNA
- NM_002224.4, XM_011514577.4, XM_017010832.2, XM_047418731.1, XM_047418732.1
- RefSeq protein
- NP_002215.2, XP_011512879.1, XP_016866321.1, XP_047274687.1, XP_047274688.1
This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010].
Gene Ontology
Biological process
Molecular function
inositol hexakisphosphate bindingmonoatomic ion channel activityinositol 1,4,5-trisphosphate-gated calcium channel activityinositol 1,4,5-trisphosphate-gated calcium channel activityinositol 1,4,5-trisphosphate-gated calcium channel activityinositol 1,4,5-trisphosphate-gated calcium channel activitycalcium channel activitycalcium ion binding
Pathways
Calcium signaling pathway - Homo sapiens (human)cGMP-PKG signaling pathway - Homo sapiens (human)Phosphatidylinositol signaling system - Homo sapiens (human)Oocyte meiosis - Homo sapiens (human)Apoptosis - Homo sapiens (human)Cellular senescence - Homo sapiens (human)Vascular smooth muscle contraction - Homo sapiens (human)Apelin signaling pathway - Homo sapiens (human)Gap junction - Homo sapiens (human)Platelet activation - Homo sapiens (human)
via MyGene.info
Gene · Ensembl
inositol 1,4,5-trisphosphate receptor type 3
- Symbol
- ITPR3
- Biotype
- Protein coding
- Organism
- Homo sapiens
- Location
- 6:33,620,331-33,696,575
- Strand
- Forward (+)
- Assembly
- GRCh38
View on Ensembl →
via Ensembl · EMBL-EBI
Wikidata facts
- Instance of
- gene
- Image
- IP3 receptor type 3 (ITPR3) - 6DQN.png
Show 9 more facts
- HomoloGene ID
- 1675
- genetic association
- morbid obesity
- found in taxon
- Homo sapiens
- exact match
- identifiers.org/ncbigene/3710
- genomic end
- 33664351
- genomic start
- 33588142
- chromosome
- human chromosome 6
- cytogenetic location
- 6p21.31
- Commons category
- ITPR3
via Wikidata · CC0