KIF1C
Sign in to saveAlso known as LTXS1, SATX2, SAX2, SPAX2, SPG58, kinesin family member 1C
Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene. Kif1C is a fast, plus-end directed microtubule motor. It takes processive 8nm steps along microtubules and can generate forces of up to 5 pN. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function. However, mutations in KIF1C lead to spastic paraplegia and cerebellar dysfunction in humans. These mutations usually result in a total loss of the protein or (partial) loss of function, such as significant lower force ou
Gene data
KIF1C- Name
- kinesin family member 1C
- Type
- protein-coding
- Aliases
- LTXS1, SATX2, SAX2, SPAX2, SPG58
The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014].
via MyGene.info
Wikidata facts
- Image
- Protein KIF1C PDB 2g1l.png
Show 5 more facts
- HomoloGene ID
- 4821
- exact match
- identifiers.org/ncbigene/10749
- genomic end
- 4931696
- genomic start
- 4997950
- cytogenetic location
- 17p13.2
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Article
4 sectionsContents
- Interactions
- References
- Further reading
- External links
Kinesin-like protein KIF1C is a protein that in humans is encoded by the KIF1C gene. Kif1C is a fast, plus-end directed microtubule motor. It takes processive 8nm steps along microtubules and can generate forces of up to 5 pN. Kif1C transports α5β1-integrins in human cells. Kif1C has been shown to be non-essential in mouse with other proteins able to perform the same function. However, mutations in KIF1C lead to spastic paraplegia and cerebellar dysfunction in humans. These mutations usually result in a total loss of the protein or (partial) loss of function, such as significant lower force output.
== Interactions ==