LAIR1

Name

leukocyte associated immunoglobulin like receptor 1

Type

protein-coding

Aliases

CD305, LAIR-1

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].

via MyGene.info

Gene · Ensembl

leukocyte associated immunoglobulin like receptor 1

Symbol

LAIR1

Biotype

Protein coding

Organism

Homo sapiens

Location

Chr HSCHR19_4_CTG3_1:334,105-353,279

Strand

Reverse (−)

Assembly

GRCh38

Wikidata facts

Instance of

gene

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