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lapaquistat

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EntityQ6488102· pop 6· linked from 91 articles

lapaquistat

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Lapaquistat (TAK-475) is a cholesterol-lowering drug candidate that was abandoned before being marketed.

Chemical data

Formula
C31H39ClN2O8
Molecular weight
603.1 g/mol
IUPAC name
2-[1-[2-[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-5H-4,1-benzoxazepin-3-yl]acetyl]piperidin-4-yl]acetic acid
SMILES
CC(C)(CN1C2=C(C=C(C=C2)Cl)[C@H](O[C@@H](C1=O)CC(=O)N3CCC(CC3)CC(=O)O)C4=C(C(=CC=C4)OC)OC)CO
InChIKey
HDGUKVZPMPJBFK-LEAFIULHSA-N
XLogP
3.2
Polar surface area
126 Ų
H-bond donors
2
H-bond acceptors
8
Formal charge
0

via PubChem

Drug data · ChEMBL

Molecule type
Small molecule

via ChEMBL · EBI

Wikidata facts

Mass
602.239
Show 4 more facts
chemical formula
C₃₁H₃₉ClN₂O₈
isomeric SMILES
CC(C)(CN1C2=C(C=C(C=C2)Cl)[C@H](O[C@@H](C1=O)CC(=O)N3CCC(CC3)CC(=O)O)C4=C(C(=CC=C4)OC)OC)CO
canonical SMILES
CC(C)(CN1C2=C(C=C(C=C2)Cl)C(OC(C1=O)CC(=O)N3CCC(CC3)CC(=O)O)C4=C(C(=CC=C4)OC)OC)CO
Commons category
Lapaquistat
Sources (2)

via Wikidata · CC0

~2 min read

Encyclopedic overview

2 sections
Contents
  • References
  • Further reading

{{Infobox drug | Verifiedfields = changed | verifiedrevid = 462088993 | IUPAC_name = (1-{[(3R,5S)-7-chloro-5-(2,3-dimethoxyphenyl)-1-(3-hydroxy-2,2-dimethylpropyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl]acetyl}piperidin-4-yl)acetic acid | image = Lapaquistat.svg | image_class = skin-invert-image

| tradename =

Excerpted from Wikipedia’s “lapaquistat” article, available under the CC BY-SA 4.0 licence.

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