lemborexant

Chemical data

Formula: C22H20F2N4O2
Molecular weight: 410.4 g/mol
IUPAC name: cis-(1R,2S)-2-[(2,4-dimethylpyrimidin-5-yl)oxymethyl]-2-(3-fluorophenyl)-N-(5-fluoro-2-pyridinyl)cyclopropane-1-carboxamide
SMILES: CC1=NC(=NC=C1OC[C@]2(C[C@H]2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C
InChIKey: MUGXRYIUWFITCP-PGRDOPGGSA-N
XLogP: 3.2
Polar surface area: 77 Å²
H-bond donors: 1
H-bond acceptors: 7
Formal charge: 0

via PubChem

Drug data · ChEMBL

Max clinical phase: Approved
Molecule type: Small molecule
First approval: 2020
Admin. routes: oral
Indications: insomnia, liver disease, obstructive sleep apnea, kidney disease

via ChEMBL · EBI

Wikidata facts

Subclass of: chemical compound
Mass: 410.155

Show 4 more facts

isomeric SMILES: CC1=NC(=NC=C1OC[C@]2(C[C@H]2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C
canonical SMILES: CC1=NC(=NC=C1OCC2(CC2C(=O)NC3=NC=C(C=C3)F)C4=CC(=CC=C4)F)C
chemical formula: C₂₂H₂₀F₂N₄O₂
Commons category: Lemborexant

Sources (3)

via Wikidata · CC0

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Encyclopedic overview

12 sections

Contents

Medical uses
Available forms
Side effects
Pharmacology
Pharmacodynamics
Pharmacokinetics
History
Society and culture
Names
Availability
Research
References

thumb|Blister pack of the orexin receptor antagonist "Lemborexant" available in Japan

Lemborexant, sold under the brand name Dayvigo, is an orexin antagonist medication which is used in the treatment of insomnia. It is indicated specifically for the treatment of insomnia characterized by difficulties with sleep onset and/or maintenance in adults. The medication is taken by mouth.

Excerpted from Wikipedia’s “lemborexant” article, available under the CC BY-SA 4.0 licence.