Structure via PubChem · Public domain (PubChem)
levamlodipine
Sign in to saveAlso known as Levoamlodipine, S-amlodipine
Levamlodipine (INN), also known as levoamlodipine or '''S-amlodipine is a pharmacologically active enantiomer of amlodipine. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent. It was approved by the U.S. FDA in December 2019 and is currently marketed under the brand name Conjupri'''.
Chemical data
- Formula
- C20H25ClN2O5
- Molecular weight
- 408.9 g/mol
- IUPAC name
- 3-O-ethyl 5-O-methyl (4S)-2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
- SMILES
- CCOC(=O)C1=C(NC(=C([C@@H]1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
- InChIKey
- HTIQEAQVCYTUBX-KRWDZBQOSA-N
- XLogP
- 3
- Polar surface area
- 99.9 Ų
- H-bond donors
- 2
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2019
- Admin. routes
- oral
- Indications
- hypertension, cardiovascular disease
via ChEMBL · EBI
Wikidata facts
- Subclass of
- amlodipine
- Mass
- 408.145
- Has use
- medication
Show 5 more facts
- chemical formula
- C₂₀H₂₅ClN₂O₅
- World Health Organisation international non-proprietary name
- levamlodipine
- canonical SMILES
- CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
- isomeric SMILES
- CCOC(=O)C1=C(NC(=C([C@@H]1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN
- Commons category
- Levamlodipine
Sources (2)
via Wikidata · CC0
~5 min read
Encyclopedic overview
6 sectionsContents
- Mechanism of action
- Pharmacokinetics and metabolism
- Clinical experience
- Safety and tolerability
- Society and culture
- References
Levamlodipine (INN), also known as levoamlodipine or '''S-amlodipine is a pharmacologically active enantiomer of amlodipine. Amlodipine belongs to the dihydropyridine group of calcium channel blocker used as an antihypertensive and antianginal agent. It was approved by the U.S. FDA in December 2019 and is currently marketed under the brand name Conjupri'.
== Mechanism of action ==
Excerpted from Wikipedia’s “levamlodipine” article, available under the CC BY-SA 4.0 licence.