Italiano
Structure via PubChem · Public domain (PubChem)
Chemical data
- Formula
- C23H22ClNO2
- Molecular weight
- 379.9 g/mol
- IUPAC name
- 2-[2-(4-chlorophenyl)-6,6-dimethyl-1-phenyl-5,7-dihydropyrrolizin-3-yl]acetic acid
- SMILES
- CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
- InChIKey
- UAWXGRJVZSAUSZ-UHFFFAOYSA-N
- XLogP
- 5.2
- Polar surface area
- 42.2 Ų
- H-bond donors
- 1
- H-bond acceptors
- 2
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Molecule type
- Small molecule
via ChEMBL · EBI
Research
157 papers- Licofelone, a potent COX/5-LOX inhibitor and a novel option for treatment of neurological disorders.Prostaglandins & other lipid mediators · 2021
- Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis.Rheumatology (Oxford, England) · 2004
- Licofelone--a novel analgesic and anti-inflammatory agent.Current topics in medicinal chemistry · 2007
- Poly-beta-amino-ester licofelone conjugates development for osteoarthritis treatment.RSC advances · 2024
- Licofelone Attenuates Acetic Acid-Induced Colitis in Rats Through Suppression of the Inflammatory Mediators.Inflammation · 2023
via PubMed
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 379.13390662399996
Show 3 more facts
- chemical formula
- C₂₃H₂₂ClNO₂
- canonical SMILES
- CC1(CC2=C(C(=C(N2C1)CC(=O)O)C3=CC=C(C=C3)Cl)C4=CC=CC=C4)C
- Commons category
- Licofelone
Sources (2)
via Wikidata · CC0
Article · Italiano
Licofelone (conosciuto anche in fase sperimentale con la sigla ML 3000) è una molecola appartenente alla classe dei farmaci antinfiammatori non steroidei (FANS). La molecola deriva dall'acido acetico ed è dotata di proprietà antinfiammatorie, antipiretiche, analgesiche e di antiaggregazione piastrinica. Il farmaco è stato sviluppato da un consorzio denominato EuroAlliance e formato dalla società farmaceutica italiana , da Merckle GmbH, e da Lacer SA.
Abstract from DBpedia / Wikipedia · CC BY-SA