Structure via PubChem · Public domain (PubChem)
lodoxamide
Sign in to saveAlso known as N,N'-(2-chloro-5-cyano-m-phenylene)dioxamate
Lodoxamide is an antiallergic pharmaceutical drug. It is marketed under the tradename Alomide in the UK. Like cromoglicic acid it acts as a mast cell stabilizer. In 2014 lodoxamide and bufrolin were found to be potent agonists at the G protein-coupled receptor 35, an orphan receptor believed to play a role in inflammatory processes, pain and the development of stomach cancer.
Chemical data
- Formula
- C11H6ClN3O6
- Molecular weight
- 311.63 g/mol
- IUPAC name
- 2-[2-chloro-5-cyano-3-(oxaloamino)anilino]-2-oxoacetic acid
- SMILES
- C1=C(C=C(C(=C1NC(=O)C(=O)O)Cl)NC(=O)C(=O)O)C#N
- InChIKey
- RVGLGHVJXCETIO-UHFFFAOYSA-N
- XLogP
- 0.5
- Polar surface area
- 157 Ų
- H-bond donors
- 4
- H-bond acceptors
- 7
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 1993
- Admin. routes
- topical
- Indications
- eye allergy
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 310.995
- Has use
- medication
Show 5 more facts
- chemical formula
- C₁₁H₆ClN₃O₆
- medical condition treated
- vernal conjunctivitis
- canonical SMILES
- C1=C(C=C(C(=C1NC(=O)C(=O)O)Cl)NC(=O)C(=O)O)C#N
- subject has role
- H1 antagonist
- Commons category
- Lodoxamide
via Wikidata · CC0
~1 min read
Encyclopedic overview
2 sectionsContents
- See also
- References
Lodoxamide is an antiallergic pharmaceutical drug. It is marketed under the tradename Alomide in the UK. Like cromoglicic acid it acts as a mast cell stabilizer. In 2014 lodoxamide and bufrolin were found to be potent agonists at the G protein-coupled receptor 35, an orphan receptor believed to play a role in inflammatory processes, pain and the development of stomach cancer.
==See also== Nedocromil Zaprinast Amlexanox Pemirolast Pamoic acid Kynurenic acid CXCL17
Excerpted from Wikipedia’s “lodoxamide” article, available under the CC BY-SA 4.0 licence.