lurbinectedin
Sign in to saveLurbinectedin, sold under the brand name Zepzelca, is a medication used for the treatment of small cell lung cancer.
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Encyclopedic overview
10 sectionsContents
- Medical uses
- Adverse effects
- Structure
- Synthesis
- Mechanism of action
- History
- Research
- Clinical Trials
- References
- External links
Lurbinectedin, sold under the brand name Zepzelca, is a medication used for the treatment of small cell lung cancer.
Lurbinectedin is a synthetic tetrahydropyrrolo [4,3,2-de]quinolin-8(1H)-one alkaloid analogue with potential antineoplastic activity. Lurbinectedin covalently binds to residues lying in the minor groove of DNA, which may result in delayed progression through S phase, cell cycle arrest in the G2/M phase and cell death.
Excerpted from Wikipedia’s “lurbinectedin” article, available under the CC BY-SA 4.0 licence.