LY6E
Sign in to saveAlso known as RIG-E, RIGE, SCA-2, SCA2, TSA-1, lymphocyte antigen 6 complex, locus E, lymphocyte antigen 6 family member E
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. Ly6E is associated with drug resistance and tumor immune escape in breast cancer. Further research is required to validate Ly6E for translation research.
Gene data
LY6E- Name
- lymphocyte antigen 6 family member E
- Type
- protein-coding
- Aliases
- RIG-E, RIGE, SCA-2, SCA2, TSA-1
This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021].
via MyGene.info
Wikidata facts
Show 5 more facts
- exact match
- identifiers.org/ncbigene/4061
- HomoloGene ID
- 56411
- genomic start
- 144099399
- genomic end
- 144105249
- cytogenetic location
- 8q24.3
Sources (3)
via Wikidata · CC0
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Article
2 sectionsContents
- References
- Further reading
Lymphocyte antigen 6E is a protein that in humans is encoded by the LY6E gene. Increased expression of Ly6E is associated with poor survival outcome in multiple malignancies as determined by a survey of more than 130 published clinical studies of gene expression studies on cancer tissue samples and adjacent normal tissues. Ly6E is associated with drug resistance and tumor immune escape in breast cancer. Further research is required to validate Ly6E for translation research.
== References ==