MAF1

Also known as MAF1 homolog, negative regulator of RNA polymerase III

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.

In the Vinony graph

Vinony's link graph records 2 inbound references to MAF1, and connects out to PubMed, human chromosome 8 and Ensembl genome database project.

It is catalogued under the topic Genes on human chromosome 8.

Vinony links it to 5 Wikipedia language editions.

Gene data

MAF1

Name: MAF1 negative regulator of RNA polymerase III
Type: protein-coding
Position: 144,103,112–144,107,618 (+)
Ensembl: ENSG00000179632
RefSeq RNA: NM_032272.5
RefSeq protein: NP_115648.2

This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase I negative regulation of transcription by RNA polymerase III negative regulation of transcription by RNA polymerase III negative regulation of transcription by RNA polymerase III

Molecular function

RNA polymerase III core binding RNA polymerase III type 1 promoter sequence-specific DNA binding RNA polymerase III type 2 promoter sequence-specific DNA binding RNA polymerase III type 3 promoter sequence-specific DNA binding protein binding GABA receptor binding

Cellular component

nucleus nucleus nucleus nucleus nucleus nucleoplasm nucleoplasm cytoplasm

Pathways

PIP3 activates AKT signaling PIP3 activates AKT signaling Signal Transduction Signal Transduction PTEN Regulation PTEN Regulation Regulation of PTEN gene transcription Regulation of PTEN gene transcription Intracellular signaling by second messengers Intracellular signaling by second messengers

via MyGene.info

Gene · Ensembl

MAF1 negative regulator of RNA polymerase III

Symbol: MAF1
Biotype: Protein coding
Organism: Homo sapiens
Location: 8:144,103,112-144,107,618
Strand: Forward (+)
Assembly: GRCh38

View on Ensembl →

via Ensembl · EMBL-EBI

Wikidata facts

Instance of: gene
Image: Cyrstal Structure of Repressor of RNA polymerase III transcription MAF1.png

Show 8 more facts

HomoloGene ID: 49867
found in taxon: Homo sapiens
exact match: identifiers.org/ncbigene/84232
genomic end: 145162514
genomic start: 144104461
chromosome: human chromosome 8
cytogenetic location: 8q24.3
expressed in: left coronary artery

Sources (4)

via Wikidata · CC0

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Encyclopedic overview

2 sections

Contents

References
Further reading

Repressor of RNA polymerase III transcription MAF1 homolog is a protein that in humans is encoded by the MAF1 gene.

This gene encodes a protein that is homologous to Maf1, a Saccharomyces cerevisiae protein which is highly conserved in eukaryotic cells. S. cerevisiae Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses Pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression.

Excerpted from Wikipedia’s “MAF1” article, available under the CC BY-SA 4.0 licence.