Structure via PubChem · Public domain (PubChem)
sotagliflozin
Sign in to saveAlso known as LX-4211, LX4211
Sotagliflozin, sold under the brand name Inpefa among others, is a medication used to reduce the risk of death due to heart failure. It is an inhibitor of sodium-glucose cotransporter 1 and 2 (SGLT1/SGLT2 inhibitor). It is taken by mouth.
Chemical data
- Formula
- C21H25ClO5S
- Molecular weight
- 424.9 g/mol
- IUPAC name
- (2S,3R,4R,5S,6R)-2-[4-chloro-3-[(4-ethoxyphenyl)methyl]phenyl]-6-methylsulfanyloxane-3,4,5-triol
- SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)SC)O)O)O)Cl
- InChIKey
- QKDRXGFQVGOQKS-CRSSMBPESA-N
- XLogP
- 3.2
- Polar surface area
- 104 Ų
- H-bond donors
- 3
- H-bond acceptors
- 6
- Formal charge
- 0
via PubChem
Drug data · ChEMBL
- Max clinical phase
- Approved
- Molecule type
- Small molecule
- First approval
- 2019
- Admin. routes
- oral
- Indications
- liver disease, diabetes mellitus, kidney disease, heart failure
via ChEMBL · EBI
Wikidata facts
- Subclass of
- chemical compound
- Mass
- 424.111123
Show 5 more facts
- Commons category
- Sotagliflozin
- subject has role
- gliflozins
- chemical formula
- C₂₁H₂₅ClO₅S
- canonical SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C3C(C(C(C(O3)SC)O)O)O)Cl
- isomeric SMILES
- CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)[C@H]3[C@@H]([C@H]([C@@H]([C@H](O3)SC)O)O)O)Cl
Sources (2)
via Wikidata · CC0
~4 min read
Encyclopedic overview
8 sectionsContents
- Medical uses
- Pharmacology
- History
- Society and culture
- Legal status
- Research
- References
- Further reading
Sotagliflozin, sold under the brand name Inpefa among others, is a medication used to reduce the risk of death due to heart failure. It is an inhibitor of sodium-glucose cotransporter 1 and 2 (SGLT1/SGLT2 inhibitor). It is taken by mouth.
The most common adverse reactions include urinary tract infection, volume depletion, diarrhea, and hypoglycemia.
Excerpted from Wikipedia’s “sotagliflozin” article, available under the CC BY-SA 4.0 licence.