MAFG

Also known as hMAF, MAF bZIP transcription factor G

Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.

Gene data

MAFG

Name: MAF bZIP transcription factor G
Type: protein-coding
Position: 81,918,270–81,927,735 (−)
Aliases: hMAF
Ensembl: ENSG00000197063
RefSeq RNA: NM_002359.4, NM_032711.4, XM_047436068.1, XM_047436069.1, XM_047436070.1
RefSeq protein: NP_002350.1, NP_116100.2, XP_047292024.1, XP_047292025.1, XP_047292026.1

Globin gene expression is regulated through nuclear factor erythroid-2 (NFE2) elements located in enhancer-like locus control regions positioned many kb upstream of alpha- and beta-gene clusters (summarized by Blank et al., 1997 [PubMed 9166829]). NFE2 DNA-binding activity consists of a heterodimer containing a ubiquitous small Maf protein (MafF, MIM 604877; MafG; or MafK, MIM 600197) and the tissue-restricted protein p45 NFE2 (MIM 601490). Both subunits are members of the activator protein-1-like superfamily of basic leucine zipper (bZIP) proteins (see MIM 165160).[supplied by OMIM, Mar 2010].

Gene Ontology

Biological process

negative regulation of transcription by RNA polymerase II regulation of DNA-templated transcription regulation of transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of gene expression regulation of epidermal cell differentiation positive regulation of transcription by RNA polymerase II

Molecular function

RNA polymerase II cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA binding DNA-binding transcription factor activity DNA-binding transcription factor activity protein binding

Cellular component

nucleus nucleus nucleus nucleoplasm

Pathways

Hemostasis Hemostasis Cellular responses to stress Cellular responses to stimuli Cellular response to chemical stress KEAP1-NFE2L2 pathway Nuclear events mediated by NFE2L2 NFE2L2 regulates pentose phosphate pathway genes Factors involved in megakaryocyte development and platelet production Factors involved in megakaryocyte development and platelet production

via MyGene.info

Wikidata facts

Image: Crystal structure of the MafA homodimer.png

Show 5 more facts

HomoloGene ID: 81816
exact match: identifiers.org/ncbigene/4097
genomic end: 81927735
genomic start: 79876146
cytogenetic location: 17q25.3

Sources (3)

via Wikidata · CC0

~5 min read

Article

10 sections

Contents

Discovery
Structure
Expression
Function
Target genes
Disease linkage
Notes
References
Further reading
External links

Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.

MafG is one of the small Maf proteins, which are basic region and leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFG is “v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G”.