Structure via PubChem · Public domain (PubChem)
montelukast
Sign in to saveAlso known as Singulair®, (R-(e))-1-(((1-(3-(2-(7-Chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methyl)cyclopropaneacetic acid, Montelukastum, Montélukast, 1-[[[(1 R)-1-[3-[(1e)-2-(7-chloro-2-Quinolinyl)ethenyl] phenyl]-3-[2-(1-hydroxy-1-methylethyl)phenyl]propyl]sulfanyl]methyl]cyclopropaneacetic acid
Montelukast, sold under the brand name Singulair among others, is a medication used in the maintenance treatment of asthma. It is generally less preferred for this use than inhaled corticosteroids. It is not useful for acute asthma attacks. Other uses include allergic rhinitis and hives of long duration. For allergic rhinitis it is a second-line treatment.
Key facts
- Drug.DrugBank
- DB00471
- Drug.Watchedfields
- changed
- Drug.verifiedrevid
- 462253627
- Drug.image
- Montelukast.svg
- Drug.image_class
- skin-invert-image
- Drug.width
- 300
- Drug.image2
- Montelukast 3D ball-and-stick.png
- Drug.image_class2
- bg-transparent
- Drug.width2
- 250
- Drug.pronounce
- mon te loo' kast
- Drug.tradename
- Singulair, others
- Drug.MedlinePlus
- a600014
- Drug.DailyMedID
- Montelukast
- Drug.pregnancy_AU
- B1
- Drug.routes_of_administration
- By mouth
- Drug.class
- Leukotriene receptor antagonist
- Drug.ATC_prefix
- R03
- Drug.ATC_suffix
- DC03
via Wikipedia infobox
Chemical data
- Formula
- C35H36ClNO3S
- Molecular weight
- 586.2 g/mol
- IUPAC name
- 2-[1-[[(1R)-1-[3-[(E)-2-(7-chloroquinolin-2-yl)ethenyl]phenyl]-3-[2-(2-hydroxypropan-2-yl)phenyl]propyl]sulfanylmethyl]cyclopropyl]acetic acid
- SMILES
- CC(C)(C1=CC=CC=C1CC[C@H](C2=CC=CC(=C2)/C=C/C3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
- InChIKey
- UCHDWCPVSPXUMX-TZIWLTJVSA-N
- XLogP
- 7.7
- Polar surface area
- 95.7 Ų
- H-bond donors
- 2
- H-bond acceptors
- 5
- Formal charge
- 0
via PubChem
Research
3,314 papers- Analysis of Neuropsychiatric Diagnoses After Montelukast Initiation.JAMA network open · 2022
- Montelukast.Drugs · 1998
- Montelukast as a potential treatment for COVID-19.Expert opinion on pharmacotherapy · 2023
- Psychiatric Adverse Effects of Montelukast-A Nationwide Cohort Study.The journal of allergy and clinical immunology. In practice · 2023
- Efficacy and safety of montelukast-levocetirizine combination therapy in combined allergic rhinitis and asthma syndrome: a systematic review and meta-analysis.The Journal of asthma : official journal of the Association for the Care of Asthma · 2025
via PubMed
Wikidata facts
- Mass
- 585.21
- Has use
- medication
Show 7 more facts
- chemical formula
- C₃₅H₃₆ClNO₃S
- medical condition treated
- asthma
- Commons category
- Montelukast
- canonical SMILES
- CC(C)(C1=CC=CC=C1CCC(C2=CC=CC(=C2)C=CC3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
- isomeric SMILES
- CC(C)(C1=CC=CC=C1CC[C@H](C2=CC=CC(=C2)/C=C/C3=NC4=C(C=CC(=C4)Cl)C=C3)SCC5(CC5)CC(=O)O)O
- defined daily dose
- 10
- legal status (medicine)
- boxed warning
Sources (8)
via Wikidata · CC0
~9 min read
Encyclopedic overview
10 sectionsContents
- Medical uses
- Pharmacology
- Adverse effects
- FDA investigation
- Drug interactions
- Society and culture
- Patents
- Use with loratadine
- Brand names
- References
Montelukast, sold under the brand name Singulair among others, is a medication used in the maintenance treatment of asthma. It is generally less preferred for this use than inhaled corticosteroids. It is not useful for acute asthma attacks. Other uses include allergic rhinitis and hives of long duration. For allergic rhinitis it is a second-line treatment.
Common side effects include abdominal pain, cough, and headache. Severe side effects may include allergic reactions, such as anaphylaxis and eosinophilia. Use in pregnancy appears to be safe. Montelukast is in the leukotriene receptor antagonist family of medications. It works by blocking the action of leukotriene D4 in the lungs resulting in decreased inflammation and relaxation of smooth muscle.
Excerpted from Wikipedia’s “montelukast” article, available under the CC BY-SA 4.0 licence.